Zusammenfassung
Orale Gabe von Dimethylamin oder Methylbenzylamin zusammen mit Natriumnitrit bewirkte eine synergistische Hemmung der Protein-Synthese in der Leber von Mäusen. Ausserdem hemmte die kombinierte Gabe von Dimethylamin und Nitrit synergistisch die Synthese nuklearer RNS in der Leber.
Letiratur
W. Lijinski andS. S. Epstein, Nature, Lond.225, 21 (1970).
F. Ender, G. Havre, A. Helgebostad, N. Koppang, R. Madsen andL. Ceh, Naturwissenschaften51, 637 (1964).
L. S. Du Plessis, J. R. Nunn andW. A. Roach, Nature, Lond.222, 1198 (1969).
E. Kroller, Dt. LebdnsmittRdsch.63, 303 (1967).—K. Mohler, andO. L. Mayrhofer, Z. Lebensmittelunters. u.-Forsch.135, 313 (1968).
G. Neurath, Experientia23, 400 (1967).
P. Marquardt andL. Hedler, Arzneimittel-Forsch.16, 778 (1966).
N. D. McGlashan, C. L. Walters andA. E. M.Xxx, Lancet2, 1017 (1968).
N. P. Sen, D. C. Smith andL. Schwinghamer, Fd. Cosmet. Toxicol.7, 301 (1969).
N. P. Sen, D. C. Smith, L. Schwinghamer andB. Howsam, Can. Inst. Food Tech. J.3, 66 (1970).
V. J. Sander, F. Schweinsberg andH. P. Menz, Hoppe-Seyler's Z. Physiol. Chem.349, 1691 (1968).
S. S. Mirvish, J. natn. Cancer Inst.44, 633 (1970).
B. Alam, I. Saporoschetz andS. S. Epstein, Nature, Lond.232, 116 (1971);232, 199 (1971).
V. J. Sanders, Hoppe-Seyler's Z. Physiol. Chem.349, 1691 (1968).
S. Asahina, M. Friedman, Y. Bishop, E. Arnold, G. Millar, M. Mishkin andS. S. Epstein, Cancer Res.31, 120 (1971).
M. Friedman, K. H. Shull andE. Farber, Biochem. biophys. Res. Commun.34, 857 (1969).
K. Burton, Biochem. J.62, 315 (1956).
S. Villa-Trevino, Biochem. J.105, 625 (1967).
M. Friedman, unpublished observations.
Author information
Authors and Affiliations
Additional information
Supported by N.I.H. Grants No. C-6516 and No. FR-05526.
Rights and permissions
About this article
Cite this article
Friedman, M.A., Millar, G., Sengupta, M. et al. Inhibition of mouse liver protein and nuclear RNA synthesis following combined oral treatment with sodium nitrite and dimethylamine or methylbenzylamine. Experientia 28, 21–23 (1972). https://doi.org/10.1007/BF01928238
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01928238