, Volume 30, Issue 2, pp 175–177 | Cite as

Blockade of the hydrosmotic effect of vasopressin by cytochalasin B

  • R. C. de Sousa
  • A. Grosso
  • C. Rufener


Sodium Pitressine Macrolide Cytochalasin Autant Modifier 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


La cytochalasine B dissocie les effets hydrosmotique et natriférique de la Pitressine sur la vessie de crapaud, en bloquant le transport d'eau sans pour autant modifier la stimulation du transport de sodium. Les interactions possibles entre le macrolide, les microfilaments et les altérations de perméabilité sont discutées.


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  1. 1.
    S. B. Carter, Endeavour31, 77 (1972).PubMedGoogle Scholar
  2. 2.
    W. Rothweiler andCh. Tamm, Experientia22, 750 (1966).Google Scholar
  3. 3.
    S. B. Carter, Nature213, 261 (1967).PubMedGoogle Scholar
  4. 4.
    N. K. Wessels, B. S. Spooner, J. F. Ash, M. O. Bradley, M. A. Luduena, E. L. Taylor, J. T. Wrenn andK. M. Yamada, Science171, 135 (1971).PubMedGoogle Scholar
  5. 5.
    L. Orci, K. H. Gabbay andW. J. Malaisse, Science175, 1128 (1972).PubMedGoogle Scholar
  6. 6.
    H. Holtzer andJ. W. Sanger, Devel. Biol.27, 444 (1972).Google Scholar
  7. 7.
    R. C. de Sousa andA. Grosso, Experientia29, 1097 (1973).PubMedGoogle Scholar
  8. 8.
    M. Rüphi, R. C. de Sousa, E. Favrod-Coune andJ. M. Posternak, Experientia28, 1391 (1972).PubMedGoogle Scholar
  9. 9.
    Studies on water flow across frog skin were discontinued due to the wide variability of hydrosmotic responses in this epithelium.Google Scholar
  10. 10.
    R. F. Kletzien andJ. F. Perdue, J. biol. Chem.248, 711 (1973).PubMedGoogle Scholar
  11. 11.
    P. G. W. Plagemann andR. D. Estensen, J. Cell Biol.55, 179 (1972).PubMedGoogle Scholar
  12. 12.
    L. D. Peachey andH. Rasmussen, J. Biophys. biochem. Cytol.10, 529 (1961).PubMedGoogle Scholar
  13. 13.
    S. K. Masur, E. Holtzman, I. L. Schwartz andR. Walter, J. Cell Biol.49, 582 (1971).PubMedGoogle Scholar
  14. 14.
    S. K. Masur, E. Holtzman andR. Walter, J. Cell Biol.52, 211 (1972).PubMedGoogle Scholar
  15. 15.
    B. P. Croker Jr, andC. C. Tisher, Kidney International1, 145 (1972).PubMedGoogle Scholar
  16. 16.
    A. Taylor, M. Mamelak, E. Reaven andR. Maffly, Science181, 347 (1973).PubMedGoogle Scholar
  17. 17.
    These authors reported also that effects of microtubular agents on toad bladder are similar to those of CB, an observation consistent with results from our laboratory. We noticed, however, that colchicine and strychnine do not alter sodium transport if added to the internal side of the skin, while addition to the external side is followed by a stimulation of sodium transport very similar to that observed with DPH7 and lanthanides.Google Scholar
  18. 18.
    R. C. de Sousa, J. Marguerat andA. Grosso, Experientia29, 749 (1973).Google Scholar
  19. 19.
    We thank Dr.G. W. G. Sharp for careful reading of the manuscript, MissD. Kaelin for technical assistance, and Sandoz Ltd for a generous gift of Syntocinon.Google Scholar
  20. 20.
    Supported by SNF grants Nos 3.567.71 and 3.8080.72.Google Scholar

Copyright information

© Birkhäuser Verlag 1974

Authors and Affiliations

  • R. C. de Sousa
    • 1
  • A. Grosso
    • 1
  • C. Rufener
    • 1
  1. 1.Département de Physiologie de l'Université Ecole de MédecineGenève 4Switzerland

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