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Synthesis of ochratoxins TA and TC, analogs of ochratoxins A and C

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Zusammenfassung

Zwei Ochratoxinanaloge, Ochratoxin TA (OTA) und TC (OTC) wurden aus Ochratoxin-α chemisch synthetisiert indem Phenylalanin und sein Äthylester im Molekül durch Tyrosin und Tyrosinäthylester substituiert wurden. Der Hühnerembryonentest ergab, dass OTC etwas toxischer und OTA etwas weniger toxisch ist als Ochratoxin A (OA).

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  10. This work was supported by the College of Agricultural and Life Sciences, The University of Wisconsin, and by contributions from various companies and associations of the food industries. The authors express their thanks to ProfessorH. K. Schnoes for his help with mass spectral measurement, to Mr.W. T. Stott for his help with the chicken embryo assay, and to Ms.A. R. Drucker for her assistance in the preparation of the manuscript.

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Authors and Affiliations

  1. Food Researach Institute and Department of Food Science, University of Wisconsin, 220 Babcack Hall, 53706, Madison, Wisconsin, USA

    Ru-Dong Wei & F. S. Chu

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  1. Ru-Dong Wei
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  2. F. S. Chu
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Wei, RD., Chu, F.S. Synthesis of ochratoxins TA and TC, analogs of ochratoxins A and C. Experientia 30, 174–175 (1974). https://doi.org/10.1007/BF01927717

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  • DOI: https://doi.org/10.1007/BF01927717

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