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Enhancement of tubular organic base accumulation in renal cortical slices by repeated administrations ofTris-hydroxymethyl aminomethane, tromethamol (THAM) to rats of different ages

Experientia volume 32, pages 1182–1184 (1976)Cite this article

Summary

After repeated THAM administrations to rats of different ages, an enhancement of THAM accumulation in renal cortical slices was observed, except in newborns. This effect can be interpreted as a specific substrate stimulation of the organic base transport system.

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References

  1. H. Bräunlich, K. Luther andS. Rudolph, Experientia30, 1314 (1974).

    PubMed  Google Scholar 

  2. H. Bräunlich, Archs. int. Pharmacodyn. Thér.216, 144 (1975).

    Google Scholar 

  3. M. Stopp andH. Bräunlich, Z. Versuchstierk.16, 131 (1974).

    Google Scholar 

  4. M. Stopp andH. Bräunlich, Acta biol. med. germ.34, 89 (1975).

    PubMed  Google Scholar 

  5. H. Rosen, Ann. N.Y. Acad. Sci.92, 414 (1961).

    PubMed  Google Scholar 

  6. J. K. Kim, G. H. Hirsch andJ. B. Hook, Pediat. Res.6, 600 (1972).

    PubMed  Google Scholar 

  7. G. H. Hirsch, Can. J. Physiol. Pharmac.50, 533 (1972).

    Google Scholar 

  8. G. H. Hirsch andA. P. Pakuts, Toxic. appl. Pharmac.32, 109 (1975).

    Google Scholar 

  9. M. H. Holmdahl andG. H. Nahas, Am. J. Physiol.202, 1011 (1962).

    PubMed  Google Scholar 

  10. B. R. Rennick, A. Rev. Pharmac.12, 141 (1972).

    Google Scholar 

  11. C. R. Ross, N. I. Pessan andA. Farah, J. Pharmac. exp. Ther.167, 235 (1969).

    Google Scholar 

  12. S. Magour, A. E. Farah andA. Sroka, J. Pharmac. exp. Ther.167, 243 (1969).

    Google Scholar 

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Author information

Affiliations

  1. Zentraler Platz, Institute of Pharmacology and Toxicology of the Friedrich-Schiller-University, DDR-69, Jena, (German Democratic Republic, DDR)

    M. Stopp & H. Bräunlich

Authors
  1. M. Stopp
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  2. H. Bräunlich
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Additional information

Acknowledgment. The authors thank MissKarin Müller for technical assistance.

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Stopp, M., Bräunlich, H. Enhancement of tubular organic base accumulation in renal cortical slices by repeated administrations ofTris-hydroxymethyl aminomethane, tromethamol (THAM) to rats of different ages. Experientia 32, 1182–1184 (1976). https://doi.org/10.1007/BF01927615

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  • DOI: https://doi.org/10.1007/BF01927615

Keywords

  • Specific Substrate
  • Transport System
  • Repeated Administration
  • THAM
  • Organic Base