, Volume 32, Issue 9, pp 1136–1138 | Cite as

Developmental characteristics of histamine methyltransferase and phenylethanolamine-N-methyltransferase of rat brain

  • E. D. Kouvelas
  • Ch. E. Savakis
  • E. Th. Tzebelikos
  • G. Bonatsos
  • S. Mitrossilis
Specialia Chimica, Biochimica


The specific activity of histamine methyltransferase of rat brain increases rapidly from the 16th until the 25th day of gestation (7 days after birth). The specific activity of phenylethanolamine-N-methyl-transferase shows a rapid incrase during the 1st and the 2nd week after birth, the adult values being obtained by the end of the 2nd week.


Histamine Developmental Characteristic Histamine Methyltransferase 
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  1. 2.
    J. P. Green inHandbook of Neurochemistry (Ed.A. Lajtha; Plenum Press, New York 1970), vol. 4, p. 221.Google Scholar
  2. 3.
    G. Kahlson andE. Rosengreen, Physiol. Rev.48, 155 (1968).PubMedGoogle Scholar
  3. 4.
    J. Balgooy, F. Marshall andE. Roberts, J. Neurochem.19, 2341 (1972).PubMedGoogle Scholar
  4. 5.
    M. J. Kuhar, K. M. Taylor andS. H. Snyder, J. Neurochem.18, 1515 (1971).PubMedGoogle Scholar
  5. 6.
    K. Taylor andS. Snyder, J. Neurochem.19, 1343 (1972).PubMedGoogle Scholar
  6. 7.
    J. Akelrod, J. biol. Chem.237, 1657 (1962).PubMedGoogle Scholar
  7. 8.
    U. S. vonEuler, Acta physiol. scand.12, 73 (1946).Google Scholar
  8. 9.
    L. A. Pohorecky, M. Zigmond, H. Karten andR. J. Wurtman, J. Pharmac. exp. Ther.165, 190 (1969).Google Scholar
  9. 10.
    R. Ciaranello, R. Barchas, G. Byers, D. Stemmle andJ. D. Barchas, Nature, Lond.221, 368 (1969).Google Scholar
  10. 11.
    J. M. Saavedra andJ. Axelrod, Proc. natn. Acad. Sci., USA70, 769 (1973).Google Scholar
  11. 12.
    E. E. Inwang, A. D. Mosnain andA. C. Sabelli, J. Neurochem.20, 1469 (1973).PubMedGoogle Scholar
  12. 13.
    A. C. Sabelli, A. G. Vazquez andD. F. Flavin, Abstracts 3rd Annual Meeting Soc. for Neurosciences, San Diego (1973), p. 26.Google Scholar
  13. 14.
    D. Brown, R. Tomchick andJ. Axelrod, J. biol. Chem.224, 2948 (1959).Google Scholar
  14. 15.
    J. C. Schwartz, C. Lampart, C. Rose, M. C. Rehault, S. Bischoff andH. Pollard, J. Neurochem.18, 1787 (1971).PubMedGoogle Scholar
  15. 16.
    L. Pearce andS. Schanberg, Science166, 1301 (1968).Google Scholar
  16. 17.
    B. A. Young, C. Pert, D. Brown, K. Taylor andS. Snyder, Science173, 247 (1971).PubMedGoogle Scholar
  17. 18.
    J.-C. Schwartz, H. Pollard, S. Bischoff andM. Verdiere-Sahque, Eur. J. Pharmac.16, 326 (1971).Google Scholar
  18. 19.
    J. T. Covle andJ. Axelrod, J. Neurochem.19, 449 (1971).Google Scholar
  19. 20.
    J. T. Coyle andJ. Axelrod, J. Neurochem.19, 1117 (1972).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1976

Authors and Affiliations

  • E. D. Kouvelas
    • 1
  • Ch. E. Savakis
    • 1
  • E. Th. Tzebelikos
    • 2
  • G. Bonatsos
    • 1
  • S. Mitrossilis
    • 1
  1. 1.Department of PhysiologyUniversity of Athens, Medical SchoolAthens(Greece)
  2. 2.Department of NeuroscienceChildren's Hospital Medical CenterMassUSA

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