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Structure-activity relationship of the cardenolide, with special reference to the substituents and configurations at C-14 and C-15

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Zusammenfassung

Es wurden die kardiotonischen Wirkungen sechs neuer Derivate von 14-Deoxy-14βH-digitoxigenin und 14-Deoxy-14β-chloro-digitoxigenin auf das isolierte Froschherz untersucht, sowie die Beziehungen zwischen deren chemischen Strukturen und Wirkungen diskutiert.

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Literatur

  1. T. Shigei andS. Mineshita, Experientia24, 466 (1968).

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Author notes

  1. T. Shigei & H. Tsuru

    Present address: Department of Pharmacology, Nagoya University, School of Medicine, Tsurumai-cho, Showa-ku, 466, Nagoya, Japan

  2. Y. Saito & M. Okada

    Present address: Tokyo Biochemical Research Institute, Takada, Toshima-ku, 171, Tokyo, Japan

Authors and Affiliations

  1. Department of Pharmacology, Nagoya University, School of Medicine, Tsurumai-cho, Showa-ku, 466, Nagoya, Japan

    Y. Saito & M. Okada

  2. Tokyo Biochemical Research Institute, Takada, Toshima-ku, 171, Tokyo, Japan

    T. Shigei & H. Tsuru

Authors
  1. T. Shigei
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  2. H. Tsuru
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  3. Y. Saito
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  4. M. Okada
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Additional information

This study was supported by a research grant (No. 78 7012) from the Ministry of Education, Japan, and by a Grant-in-Aid from Tokyo Biochemical Research Foundation.

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Shigei, T., Tsuru, H., Saito, Y. et al. Structure-activity relationship of the cardenolide, with special reference to the substituents and configurations at C-14 and C-15. Experientia 29, 449–450 (1973). https://doi.org/10.1007/BF01926775

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  • DOI: https://doi.org/10.1007/BF01926775

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