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Experientia

, Volume 28, Issue 8, pp 962–964 | Cite as

N α -carbamoyl-2-O-methyltyrosine-oxytocin and 1–6α deamino cystathionine-2-O-methyltyrosine oxytocin: Two antagonists of oxytocin on amphibian epithelial cell receptors

  • T. Barth
  • S. Jard
  • F. Morel
  • M. Montegut
Article

Keywords

Sodium Epithelial Cell Cell Receptor Oxytocin Deamino 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Résumé

La Nα-Carbamoyl-2-O-Methyltyrosine ocytocine et la 1–6α déaminocystathionine 2-O-Methyltyrosine ocytocine inhibent les effets hydroosmotique (augmentation de la perméabilité osmotique à l'eau de la vessie de Grenouille) et natriférique (stimulation du transport actif de sodium par la peau) de l'ocytocine. L'inhibition observée est de nature compétitive. Les affinités respectives de ces deux analogues, exprimées en % de l'affinité de l'ocytocine, sont de 0,012 et 0,36 sur le test natriférique et de 0,11 et 1,1 sur le test hydroosmotique.

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Literatur

  1. 1.
    J. Rudinger andI. Krejčf, Handb. exp. Pharmak.23, 748 (1968).Google Scholar
  2. 2.
    A. Chimiak, K. Eisler, K. Jost andRudinger, Colln Czech. chem. Commun.33, 2918 (1968).Google Scholar
  3. 3.
    K. Jošt, in preparation.Google Scholar
  4. 4.
    The authors are very much indebted to Dr.K. Jošt for his kind gift of the oxytocin analogues used in this study.Google Scholar
  5. 5.
    J. Bourguet andS. Jard, Biochim. biophys. Acta88, 442 (1964).PubMedGoogle Scholar
  6. 6.
    P. Eggena, I. L. Schwartz andR. Walter, J. gen. Physiol.52, 465 (1968).PubMedGoogle Scholar
  7. 7.
    H. H. Ussing andZ. Zerahn, Acta physiol. scand.23, 110 (1951).PubMedGoogle Scholar
  8. 8.
    F. Morel, M. Odier etC. Lucarain, J. Physiol., Paris53, 757 (1961).Google Scholar
  9. 9.
    J. Orloff andJ. S. Handler, J. clin. Invest.41, 702 (1962).PubMedGoogle Scholar
  10. 10.
    F. Bastide andS. Jard, Biochim. biophys. Acta150, 113 (1968).PubMedGoogle Scholar
  11. 11.
    P. Eggena, I. L. Schwartz andR. Walter, J. gen. Physiol.56, 250 (1970).PubMedGoogle Scholar
  12. 12.
    S. Jard, R. M. Rajerison andM. Montegut, Biochim. biophys. Acta196, 85 (1970).PubMedGoogle Scholar
  13. 13.
    F. Morel andF. Bastide, in:Oxytocin, Vasopressin and their Structural Analogues (Ed.J. Rudinger; Pergamon Press, New York 1964), p. 47.Google Scholar
  14. 14.
    T. Barth, S. Jard, F. Morel andM. Montegut, in Experientia28, 967 (1972).Google Scholar
  15. 15.
    I. Krejčí, in preparation.Google Scholar

Copyright information

© Birkhäuser Verlag 1972

Authors and Affiliations

  • T. Barth
    • 1
    • 2
  • S. Jard
    • 1
    • 2
  • F. Morel
    • 1
    • 2
  • M. Montegut
    • 1
    • 2
  1. 1.Institute of Organic Chemistry and BiochemistryCzechoslovak Academy of SciencePrague 6(Czechoslovakia)
  2. 2.Laboratoire de Physiologie cellulaireCollège de FranceParis 5e(France)

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