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Some observations on the mechanism of action of baclofen (β-chlorophenyl-γ-amino-butyric acid)

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Riassunto

Il Baclofen (acido β-clorofenil-γ-aminobutirrico), a differenza del GABA, non modifica la conduttanza di membrana della fibra muscolare di aragosta. Il Baclofen riduce la liberazione di acetilcolina dal midollo spinale di rana; tale effetto è minore di quello prodotto dal GABA. Le due sostanze sembrano agire attraverso differenti meccanismi.

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Authors and Affiliations

  1. Department of Pharmacology, St. Bartholomew's Hospital Medical College, University of London, Charterhouse Square, EC1M 6BQ, London, England

    A. Nistri & A. Constanti

Authors
  1. A. Nistri
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  2. A. Constanti
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Additional information

We wish to thank ProfessorJ. P. Quilliam for his helpful discussion and Ciba Laboratories for the gift of baclofen. This work was supported in part by a grant from the Governors of St. Bartholomew's Hospital.

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Nistri, A., Constanti, A. Some observations on the mechanism of action of baclofen (β-chlorophenyl-γ-amino-butyric acid). Experientia 31, 64–65 (1975). https://doi.org/10.1007/BF01924681

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