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Inhibition of macromolecular synthesis in the malarial parasites by inhibitors of proteolytic enzymes

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Zusammenfassung

Nachweis, dass diverse Hemmstoffe der proteolytischen Enzyme den Einbau ihrer Vorgänger in Protein und RNS vonPlasmodium berghei bei in vitro-Kultur in Mäuse-Erythrozyten verhindern, eine Hemmung, die teilweise durch Aminosäuren rückgängig gemacht wird. Diese Daten sprechen für einen Aminosäure-Entzug durch die Proteinase-Hemmstoffe im Parasiten, wobei der Hämoglobinabbau blockiert wird.

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Literatur

  1. M. R. Levy andS. C. Chou, Biochim. biophys. Acta334, 423 (1974).

    Article  CAS  Google Scholar 

  2. M. R. Levy, W. A. Siddiqui andS. C. Chou, Nature, Lond.247, 546 (1974).

    Article  CAS  PubMed  Google Scholar 

  3. J. D. Fulton andP. T. Grant, Biochem. J.63, 274 (1956).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. H. Polet, N. D. Brown andD. R. Angel, Proc. Soc. exp. Biol. Med.131, 1215 (1969).

    Article  CAS  PubMed  Google Scholar 

  5. R. J. Cenedella, H. Rosen, C. R. Angel andL. H. Saxe, Am. J. trop. Med. Hyg.17, 800 (1968).

    Article  CAS  PubMed  Google Scholar 

  6. R. L. Ladda, Milit. Med.134, 825 (1969).

    Article  CAS  Google Scholar 

  7. W. A. Siddiqui, M. R. Levy, J. V. Schnell andS. C. Chou, submitted for publication.

  8. T. Aoyagi, S. Kunimoto, H. Morishima, T. Takeuchi andH. Umezawa, J. Antibiot.24, 687 (1971).

    Article  CAS  Google Scholar 

  9. H. Suda, T. Aoyagi, M. Hamada, T. Takeuchi andH. Umezawa, J. Antibiot.25, 265 (1972).

    Article  Google Scholar 

  10. P. L. Trigg andW. E. Gutteridge, Parasitology62, 113 (1971).

    Article  CAS  PubMed  Google Scholar 

  11. J. E. Byfield andO. H. Scherbaum, Analyt. Biochem.17, 434 (1966).

    Article  CAS  PubMed  Google Scholar 

  12. S. C. Chou, H. Y. M. Pan, P. Heu andK. A. Conklin, Analyt. Biochem.57, 62 (1974).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Faculty of Biological Sciences, Southern Illinois University, 62025, Edwardsville, Illinois, USA

    M. R. Levy & Shao-Chia Chou

  2. Department of Pharmacology, University of Hawaii, 3675 Kilauea Avenue, 96816, Honolulu, Hawaii, USA

    M. R. Levy & Shao-Chia Chou

Authors
  1. M. R. Levy
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  2. Shao-Chia Chou
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Additional information

Acknowledgment: Pepstatin, chymostatin, and leupeptin were generously provided by Dr.H. Umezawa of the Microbial Research Foundation, Tokyo. This work was supported by the S.I.U. Office of Research and Projects.John Wuellener provided technical assistance. The strain ofP. berghei was provided by Dr.Coy Fitch.

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Levy, M.R., Chou, SC. Inhibition of macromolecular synthesis in the malarial parasites by inhibitors of proteolytic enzymes. Experientia 31, 52–54 (1975). https://doi.org/10.1007/BF01924675

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