Abstract
17β-estradiol (E2) and progesterone (P) treatment of immature female rats (10 μg/100 g body weight) respectively resulted in 1.38-fold (p<0.02) and 1.42-fold (p<0.02) increase in the uterine polyamine oxidase activity, and 2.45-fold (p<0.001) and 1.43-fold (p<0.02) increase in the uterine diamine oxidase activity, as compared to the controls. E2 caused a 5-fold (p<0.05) and a 1.36-fold (p<0.05) increase in putrescine and spermidine concentration respectively in rat uterus. Increases of 1.7-fold (p<0.02) and 1.6-fold (p<0.05) in putrescine and spermine concentration were determined in the P-treated uterus, as compared to the controls. The spermidine/spermine ratio, which is regarded as an index of growth rate, was higher in the E2-treated uterus and lower in the P-treated uterus than in the control uterus. No statistically significant hormonal effects were estimated in the immature liver. The data reported suggest the possibility of an involvement of polyamine-oxidizing enzymes in the modulation of polyamine concentrations in rat uterus by the female sex hormones.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Tabor, C. W., and Tabor, H., A. Rev. Biochem.53 (1985) 749.
Branham, W. S., Leamonds, M. L., and Sheehan, D. M., J. Steroid Biochem.29 (1988) 153.
Limma, G., and Shiu, R. P. C., Cancer Res.45 (1985) 2466.
Kaye, A. M., Icekson, I., and Lindner, H. R., Biochim. biophys. Acta252 (1971) 150.
Cohen, S., O'Malley, B. W., and Stastny, M., Science170 (1970) 336.
Fogel, W. A., Agents Actions18 (1986) 44.
Sessa, A., and Perin, A., Pharmac. Res. Commun.20 (1988) 181.
Seiler, N., in: The Physiology of Polyamines, vol. 1, p. 159. Eds U. Bachrach and Y. Heimer. CRC Press, Boca Raton 1989.
Sessa, A., and Perin, A., Agents. Actions43 (1994) 69.
Pavlov, V., Nikolov, I., Damjanov, D., and Dimitrov, O., Experientia47 (1991) 1209.
Nikolov, I., Pavlov, V., Minkov, I., and Damjanov, D., Experientia46 (1990) 765.
Hayashi, H., Yoshida, H., Hashimoto, F., and Okazeri, S., Biochim. biophys. Acta991 (1989) 310.
Fujita, K., Nagatsu, T., and Shinpo, K., in: Methods in Biogenic Amine Research, p. 741. Eds S. Parvez, T. Nagatsu and H. Parvez. Elsevier Science Publishers, Amsterdam 1983.
Dimitrov, O., Pavlov, V., and Jotova, I., Modern Med.5–6 (1995) 18.
Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. biol. Chem.193 (1951) 265.
Perin, A., Sessa, A., and Desiderio, M. A., in: Structure and Functions of Amine Oxidases, p. 179. Ed. B. Mondovi, CRC press, Boca Raton 1985.
Kay, J. E., and Lindsay, V. J., Biochem. J.132 (1973) 791.
Fong, J. S., Heller, J. S., and Canellakis, E. S., Biochim. biophys. Acta428 (1976 456.
Holm, I., Persson, L., Stjernborg, L., Thorsson, L., and Heby, O., Biochem. J.258 (1989) 343.
Sessa, A., Desiderio, M. A., and Perin, A., Agents Actions29 (1990) 162.
Russell, D. H., and Durie, B. J. M., Prog. Cancer Res.8 (1982) 3.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dimitrov, O., Pavlov, V. & Jotova, I. Effects of female sex hormones on polyamine-oxidizing enzyme activities and polyamine concentrations in immature rat uterus and liver. Experientia 52, 795–798 (1996). https://doi.org/10.1007/BF01923991
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01923991