Riassunto
La 5-fluorodeossiuridina, unita covalentemente alla albumina di coniglio, è liberata in forma attiva dopo penetrazione del coniugato dentro le cellule.
Reference
M. Derenzini, L. Fiume, V. Marinozzi, A. Mattioli, L. Montanaro andS. Sperti, Lab. Invest.29, 150 (1973).
G. Barbanti-Brodano andL. Fiume, Nature New Biol.243, 281 (1973).
L. Fiume andG. Barbanti-Brodano, Experientia30, 76 (1974).
G. Barbanti-Brodano, M. Derenzini andL. Fiume, Nature, Lond.248, 63 (1974).
J. V. Simson andS. S. Spicer, Int. Rev. exp. Path.12, 79 (1973).
R. Van Furth, Z. A. Cohn, G. J. Hirsch, J. H. Humphrey, W. G. Spector andH. L. Langevoort, Bull. Wld Hlth Org.46, 845 (1972).
R. Van Furth andM. M. C. Diesselhoff-den Dulk, J. exp. Med.132, 813 (1970).
E. A. Gall andT. B. Mallory, Am. J. Path.18, 381 (1942).
K. Akazaki, Acta path. jap.3, 24 (1953).
A. H. T. Robb-Smith, J. Path. Bact.47, 457 (1938).
H. Bush, E. Fujiwara andD. C. Firszt, Cancer Res.31, 371 (1961).
T. Ghose, R. C. Nairn andJ. E. Fothergill, Nature, Lond.196, 1108 (1962).
A. Trouet, D. Deprez-de Campenere andC. De Duve, Nature New Biol.239, 110 (1972).
G. Sokal, A. Trouet, J. L. Milchaux andG. Cornu, Eur. J. Cancer9, 391 (1973).
P. Roy-Burman,Recent Results in Cancer Research No. 25 (Springer-Verlag, Berlin, Heidelberg, New York 1970).
T. L. Goodfriend, L. Levine andG. D. Fasman, Science144, 1344 (1964).
J. J. Harvey andJ. East, Int. Rev. exp. Path.10, 265 (1971).
J. M. Hoskins,Virological Procedures (Butterworths, London 1967).
Acknowledgment. We thank Mr.L. Franchi and Mr.A. Mattioli for the excellent technical assistance. This investigation was supported by grants from C.N.R. (Rome) and by Pallotti's legacy for Cancer Research.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Barbanti-Brodano, G., Fiume, L. In vitro effect of a 5-fluorodeoxyuridine albumin conjugate on tumour cells and on peritoneal macrophages. Experientia 30, 1180–1182 (1974). https://doi.org/10.1007/BF01923677
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01923677