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The inhibitory effect of toluidine blue and methylene blue on rat mast cell damage by promethazine, chlorpromethazine and chlorpromazine. Its reversal by glucose

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Resumen

Se demuestra que la ación de los antihistamínicos prometazina, clorprometazina, y clorpromazina sobre los mastocitos de la rata es inhibida por el azul de toluidina y el azul de metileno. La glucosa revierte la acción inhibitoria de estos colorantes sobre la clorpromazina y la prometazina, sugeriendo que ellos actúan bloqueando el metabolismo celular. Se concluye que además de su acción lítica sobre los mastocitos de la rata, los antihistamínicos también actúan por un mecanismo que necesita de energia.

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Authors and Affiliations

  1. Departamento de Morfologia, Faculdade de Medicina, Caixa postal 301, 14100, Ribeirao Preto, S. P., Brazil

    I. Vugman & J. M. Gomez Rodrigues

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  1. I. Vugman
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  2. J. M. Gomez Rodrigues
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Vugman, I., Gomez Rodrigues, J.M. The inhibitory effect of toluidine blue and methylene blue on rat mast cell damage by promethazine, chlorpromethazine and chlorpromazine. Its reversal by glucose. Experientia 30, 1178–1180 (1974). https://doi.org/10.1007/BF01923676

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