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Tremorogenic effect of thyrotropin releasing hormone in rats

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Zusammenfassung

Thyrotropin-Releasing Hormon (TRH) erzeugt unmittelbar nach i.v. Injektion an Pentobarbital-narkotisierten Ratten einen feinschlägigen Tremor und Haarsträuben. Diese Symptome werden durch eine direkte zentralnervöse Wirkung von TRH und nicht durch Stimulation der Schilddrüse ausgelöst. Die Wirkung ist dosisabhängig und spezifisch für das Tripeptid pGlu-His-Pro.

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Author information

Authors and Affiliations

  1. Biological Laboratories, Ciba-Geigy AG, CH-4002, Basel, Switzerland

    L. Schenkel-Hulliger, W. P. Koella, A. Hartmann & L. Maître

Authors
  1. L. Schenkel-Hulliger
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  2. W. P. Koella
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  3. A. Hartmann
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  4. L. Maître
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Additional information

Acknowledgments. The authors gratefully acknowledge the advice of Dr.P. A. Desaulles and Dr.W. Rittel and the skilled technical assistance of Mr.B. Latscha and Mr.J. C. Dalmer.

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Schenkel-Hulliger, L., Koella, W.P., Hartmann, A. et al. Tremorogenic effect of thyrotropin releasing hormone in rats. Experientia 30, 1168–1170 (1974). https://doi.org/10.1007/BF01923670

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  • DOI: https://doi.org/10.1007/BF01923670

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