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Stereospecificity of oxotremorine antagonists

  • Pharmacologica
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Zusammenfassung

Die optischen Antipoden der 3 sehr wirksamen Oxotremorinantagonisten, N-(1-Methyl-4-pyrrolidino-2-butinyl)pyrrolidon, N-(1-Methyl-4-pyrrolidino-2-butinyl)succinimid und N-(1-Methyl-4-perhydroazepino-2-butinyl)succinimid, sind hergestellt und auf ihre pharmakologische Aktivität geprüft worden: Die (+)-Antipoden, die R-Konfiguration haben, wurden als Träger der Aktivität erkannt, während die (−)-Antipoden praktisch unwirksam sind.

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Authors and Affiliations

  1. Department of Organic Chemistry, Faculty of Pharmacy, University of Uppsala, Box 574, S-751 23, Uppsala, Sweden

    R. Dahlbom, Å. Lindquist, S. Lindgren, U. Svensson, B. Ringdahl & M. R. Blair Jr.

  2. Research Laboratories, Astra Pharmaceutical Products Inc., 01606, Worcester, Massachusetts, USA

    R. Dahlbom, Å. Lindquist, S. Lindgren, U. Svensson, B. Ringdahl & M. R. Blair Jr.

Authors
  1. R. Dahlbom
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  2. Å. Lindquist
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  3. S. Lindgren
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  4. U. Svensson
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  5. B. Ringdahl
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  6. M. R. Blair Jr.
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Dahlbom, R., Lindquist, Å., Lindgren, S. et al. Stereospecificity of oxotremorine antagonists. Experientia 30, 1165–1167 (1974). https://doi.org/10.1007/BF01923668

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