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Experientia

, Volume 48, Issue 1, pp 50–54 | Cite as

Proopiomelanocortin expression in the skin during induced hair growth in mice

  • A. Slominski
  • R. Paus
  • J. Mazurkiewicz
Research Articles

Abstract

We demonstrate for the first time a hair cycle-dependent gene and protein expression of proopiomelanocortin in mouse skin in vivo. Northern blot detected POMC mRNA with an apparent size of 0.9 kb in anagen but not telogen skin. Western blot emphasized a specific protein of 30–33 kDa recognized by anti β-endorphin in late but not early anagen or telogen skin. By immunocytochemistry, β-endorphin antigen was localized in the sebaceous gland in a hair cycle dependent manner.

Key words

Proopiomelanocortin hair growth skin C57B1/6 mice β-endorphin 

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Copyright information

© Birkhäuser Verlag 1992

Authors and Affiliations

  • A. Slominski
    • 1
  • R. Paus
    • 2
  • J. Mazurkiewicz
    • 3
  1. 1.Department of Immunology and MicrobiologyAlbany Medical CollegeAlbanyUSA
  2. 2.Department of Anatomy, Cell Biology and NeurobiologyAlbany Medical CollegeAlbanyUSA
  3. 3.Department of Dermatology, University Hospital R. VirchowFreie Universität BerlinBerlin 65(Germany)

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