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A new biological activity for the neuropeptide FMRFamide: experimental evidence for a secretagogue effect on amylase secretion in the scallopPecten maximus

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Abstract

FMR Famide immunoreactivity in the digestive tract of the bivalve molluscPecten maximus was investigated by immunocytochemistry. Positive FMRFamide-like immunoreactivity was detected in nerve fibres in close contact with exocrine α amylase secreting cells. Physiological studies on enzymatically dissociated cells of the stomach-digestive gland complex demonstrated the involvement of FMR Famide and analogues in the control of α amylase release from the cells. The FMRF Famide-induced secretion was shown to be time- and dose-dependent. In contrast to most naturally occurring vertebrate secretagogues which are hormones, FMRFamide appears to work in our in vitro system as a paracrine factor.

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Authors and Affiliations

  1. Laboratoire de Biologie et Biotechnologies Marines, IBBA, IFREMER Unité de Recherches Marines 14, Université de Caen, Esplanade de la Paix, F-14032, Caen Cedex, France

    P. Favrel, W. Giard & E. Boucaud-Camou

  2. CERAM, Faculté des Sciences Saint-Jérôme, F-13397, Marseille Cedex 20, France

    N. Benlimane

  3. Département de Physiologie et Neurophysiologie, CNRS URA 205, Faculté des Sciences Saint-Jérôme, F-13397, Marseille Cedex 20, France

    M. Henry

Authors
  1. P. Favrel
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  2. W. Giard
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  3. N. Benlimane
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  4. E. Boucaud-Camou
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  5. M. Henry
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Favrel, P., Giard, W., Benlimane, N. et al. A new biological activity for the neuropeptide FMRFamide: experimental evidence for a secretagogue effect on amylase secretion in the scallopPecten maximus. Experientia 50, 1106–1110 (1994). https://doi.org/10.1007/BF01923468

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  • DOI: https://doi.org/10.1007/BF01923468

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