, Volume 50, Issue 11–12, pp 1085–1091 | Cite as

Heat shock response in the central nervous system

  • W. J. Koroshetz
  • J. V. Bonventre
Multi-Author Reviews


The heat shock response is induced in nervous tissue in a variety of clinically significant experimental models including ischemic brain injury (stroke), trauma, thermal stress and status epilepticus. Excessive excitatory neurotransmission or the inability to metabolically support normal levels of excitatory neurotransmission may contribute to neuronal death in the nervous system in many of the same pathophysiologic circumstances. We demonstrated that in vitro glutamate-neurotransmitter induced excitotoxicity is attenuated by the prior induction of the heat shock response. A short thermal stress induced a pattern of protein synthesis characteristic of the highly conserved heat shock response and increased the expression of heat shock protein (HSP) mRNA. Protein synthesis was necessary for the neuroprotective effect. The study of the mechanisms of heat shock mediated protection may lead to important clues as to the basic mechanisms underlying the molecular actions of the HSP and the factors important for excitotoxic neuronal injury. The clinical relevance of these findings in vitro is suggested by experiments performed by others in vivo demonstrating that pretreatment of animals with a submaximal thermal or ischemis stress confers protection from a subsequent ischemic insult.

Key words

Excitotoxicity stroke stress response neuro protection ischemia brain neuron 


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Copyright information

© Birkhäuser Verlag Basel 1994

Authors and Affiliations

  • W. J. Koroshetz
    • 1
  • J. V. Bonventre
    • 2
  1. 1.Neurology and Medical Service, Massachusetts General HospitalHarvard Medical School, Kennedy 915, Massachusetts General HospitalBostonUSA
  2. 2.Medical Service, Massachusetts General HospitalHarvard Medical School, Suite 4002, Massachusetts General Hospital EastCharlestownUSA

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