Abstract
Agglutinins were identified in whole body extracts of aquatic insects by means of murine tumor cell agglutination, using sarcoma 180 ascites, Ehrlich, and MM-46 cells. Screening revealed agglutinins in 5 of 10 of the larvae tested, and in 2 of 6 of the water-dwelling adult insects;Gerris paludum insularis andGyrinus japonicus. Only the agglutinin from adultG. paludum also agglutinated human erythrocytes. An ascites tumor was converted into a solid form in vivo after administration ofG. paludum agglutinin. The observation that these aquatic insect agglutinins preferentially agglutinate tumor cells has considerable implications in terms of anti-tumor effects such as inhibition of cell proliferation and metastasis.
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Kawauchi, H., Hosono, M., Takayanagi, Y. et al. Agglutinins from aquatic insects—tumor cell agglutination activity. Experientia 49, 358–361 (1993). https://doi.org/10.1007/BF01923422
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DOI: https://doi.org/10.1007/BF01923422