, Volume 49, Issue 4, pp 332–334 | Cite as

Tissue-specific modulation of rat glucocorticoid receptor binding activity by melatonin

  • P. St. Persengiev
  • I. I. Kondova
Experimental World Research Articles


The effect of melatonin and 2-Iodomelatonin on nuclear and cytosolic glucocorticoid receptors in the brain, pituitary, thymus and liver has been examined. The results indicate that both melatonin and 2-Iodomelatonin administration is associated with marked changes in the density and the affinity of cytosolic and nuclear forms of glucocorticoid receptors. These observations are discussed in the context of a possible involvement of pineal melatonin in the mechanisms regulating the behaviour and metabolism of steroid receptors.

Key words

Melatonin 2-Iodomelatonin glucocorticoid receptors brain thymus liver pituitary 


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Copyright information

© Birkhäuser Verlag Basel 1993

Authors and Affiliations

  • P. St. Persengiev
    • 1
  • I. I. Kondova
    • 1
  1. 1.Department of Immunoneuroendocrinology, Institute of Biology and Immunology of ReproductionBulgarian Academy of SciencesSofia(Bulgaria)

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