Tissue-specific modulation of rat glucocorticoid receptor binding activity by melatonin
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The effect of melatonin and 2-Iodomelatonin on nuclear and cytosolic glucocorticoid receptors in the brain, pituitary, thymus and liver has been examined. The results indicate that both melatonin and 2-Iodomelatonin administration is associated with marked changes in the density and the affinity of cytosolic and nuclear forms of glucocorticoid receptors. These observations are discussed in the context of a possible involvement of pineal melatonin in the mechanisms regulating the behaviour and metabolism of steroid receptors.
Key wordsMelatonin 2-Iodomelatonin glucocorticoid receptors brain thymus liver pituitary
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