Summary
Dopamine-β-hydroxylase (DBH) activity was higher in the serum, the mesenteric artery and the cerebral cortex of 4-week-old stroke-prone spontaneously hypertensive rats (SHRSP), and lower in the nucleus tractus solitarii than it was in spontaneously hypertensive rats (SHR).
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References
K. Okamoto, Folia endocr. jap.38, 782 (1962).
K. Okamoto and K. Aoki, Jap. Circul. J.27, 282 (1963).
T. Nagatsu, T. Kato, Y. Numata (Sudo), T. Ikuta, H. Umezawa, M. Matsuzaki and T. Takeuchi, Nature251, 630 (1974).
T. Nagatsu, T. Ikuta, Y. Numata (Sudo), T. Kato, M. Sano, I. Nagatsu, H. Umezawa, M. Matsuzaki and T. Takeuchi, Science191, 290 (1976).
T. Nagatsu, T. Kato, Y. Numata (Sudo), K. Ikuta, H. Kuzuya, H. Umezawa, M. Matsuzaki and T. Takeuchi, Experientia31, 767 (1975).
T. Nagatsu, T. Kato, Y. Numata (Sudo), K. Ikuta, M. Sano, I. Nagatsu, H. Umezawa, M. Matsuzaki and T. Takeuchi, Jap. J. Pharmac.27, 531 (1977).
K. Okamoto, Y. Yamori and A. Nagaoka, Circ. Res.34/35, 143 (1974).
M. Palkovits, Brain Res.59, 449 (1973).
T. Kato, H. Kuzuya and T. Nagatsu, Biochem. Med.10, 320 (1974).
T. Nagatsu, M. Levitt and S. Udenfriend, J. biol. Chem.239, 2910 (1964).
T. Nagatsu, in: Biochemistry of Catecholamines, p. 158. University of Tokyo Press and University Park Press, Tokyo and Baltimore 1973.
A. Nagaoka and W. Lovenberg, Life Sci.19, 29 (1976).
N. Doba and D. J. Reis, Circ. Res.34, 293 (1974).
W. de Jong and M. Palkovits, Life Sci.18, 61 (1976).
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The authors wish to thank Prof. Masao Sano (Nagoya University) for his aid in dissecting the nucleus tractus solitarii and the locus coeruleus.
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Nagatsu, T., Kato, T., Hashimoto, Y. et al. Dopamine-β-hydroxylase activity in stroke-prone spontaneously hypertensive rats. Experientia 34, 305–306 (1978). https://doi.org/10.1007/BF01923000
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DOI: https://doi.org/10.1007/BF01923000