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On the synthesis of serine and homoserine samples asymmetrically labelled with tritium and deuterium in the hydroxymethylene group

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Summary

(1 R) [1-3H,2H1] 3-Phenylpropanol, the key intermediate in the synthesis of (4 R) [4-3H,2H1] D, L-homoserine and of the (4 S)-isomer, is obtained from (1 S) [1-2H1] 3-phenylpropanol and (1 RS) [1-3H] ethanol upon incubation with yeast alcohol dehydrogenase and NAD+; under similar conditions 2-phenylethanol undergoes very small exchange with [1-2H2] ethanol.

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Authors and Affiliations

  1. Istituto di Chimica del Politecnico, Centro del CNR per la Chimica delle Sostanze Organiche Naturali, I-20133, Milano, (Italy)

    C. Fuganti, D. Ghiringhelli & P. Grasselli

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  1. C. Fuganti
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  2. D. Ghiringhelli
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  3. P. Grasselli
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Fuganti, C., Ghiringhelli, D. & Grasselli, P. On the synthesis of serine and homoserine samples asymmetrically labelled with tritium and deuterium in the hydroxymethylene group. Experientia 34, 297–298 (1978). https://doi.org/10.1007/BF01922993

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