, Volume 34, Issue 9, pp 1227–1228 | Cite as

Superiority of human complement for assaying bacterial lipopolysaccharides by their anticomplementary activity

  • J. N. Saddler
  • A. C. Wardlaw


In assaying bacterial lipopolysaccharides (LPS) for anticomplementary activity, human complement (C) allowed detection of approximately 200 times smaller amounts of LPS than guinea-pig C. Pig C was slightly inferior to human.


Bacterial Lipopolysaccharide Human Complement Anticomplementary Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    S.E. Greisman and R.B. Homick, Proc. Soc. exp. Biol. Med.131, 1154 (1969).PubMedGoogle Scholar
  2. 2.
    W.M. Wolff, J.H. Mulholland and B. Ward, J. Lab. clin. Med.65, 268 (1965).PubMedGoogle Scholar
  3. 3.
    R.T. Smith and L. Thomas, J. expl. Med.104, 217 (1956).Google Scholar
  4. 4.
    K.C. Milner and R.A. Finkelstein, J. infect. Dis.116, 529 (1976).Google Scholar
  5. 5.
    J.F. Cooper, J. Levin and U.N. Wagner, J. Lab. clin. Med.76, 138 (1971).Google Scholar
  6. 6.
    A.W. Bernheimer (ed), Mechanisms in Bacterial Toxinology, p. 217. Wiley & Sons, New York 1976.Google Scholar
  7. 7.
    L. Pillemer, M.D. Schoenberg, L. Blum and L. Wurz, Science122, 545 (1955).PubMedGoogle Scholar
  8. 8.
    H. Gewurz, S.E. Mergenhagen, A. Nowotny and J.K. Phillips, J. Bact.95, 397 (1968).PubMedGoogle Scholar
  9. 9.
    S.E. Mergenhagen, R. Snyderman, H. Gewurz and H.S. Shin, Curr. Top. Micro.50, 37 (1969).Google Scholar
  10. 10.
    C. Galanos, E.Th. Rietschel, O. Luderitz and O. Westphal, Eur. J. Biochem.19, 143 (1971).PubMedGoogle Scholar
  11. 11.
    O. Westphal, O. Luderitz, E. Eichenberger and W. Keiderling, Z. Naturforschg.7b, 536 (1952).Google Scholar
  12. 12.
    G. Keloti and W.H. Lederer, in: Handbook of Micromethods for the Biological Sciences, p. 3. Van Nostrand Reinhold Co., New York 1974.Google Scholar
  13. 13.
    E.A. Kabat and M.M. Mayer, in: Experimental Immunochemistry, 2nd edn., p. 97. Charles C. Thomas, Illinois 1961.Google Scholar
  14. 14.
    H.G. Macrmorine, A.C. Wardlaw and J.C.W. Weber, J. Immun.94, 611 (1965).PubMedGoogle Scholar
  15. 15.
    M. Loss, D. Bitter-Suermann and M. Dierich, J. Immun.112, 935 (1974).PubMedGoogle Scholar
  16. 16.
    C. Galanos and O. Luderitz, Eur. J. Biochem.65, 403 (1976).PubMedGoogle Scholar
  17. 17.
    D.P. Fine, J. Immun.112, 763 (1974).PubMedGoogle Scholar
  18. 18.
    D. Bitter-Suermann, V. Hadding, H.U. Schorlemmer, M. Limbert, M. Dierich and P. Dukor, J. Immun.115, 425 (1975).PubMedGoogle Scholar
  19. 19.
    K. Rother, U. Hadding and G. Till, Komplement Biochemie und Pathologie. Steinkopf Press, Darmstadt 1974.Google Scholar
  20. 20.
    J. van Noordwijk and Y. de Jong, J. Biol. Standard,4, 131 (1976).Google Scholar

Copyright information

© Birkhäuser Verlag 1977

Authors and Affiliations

  • J. N. Saddler
    • 1
  • A. C. Wardlaw
    • 1
  1. 1.Microbiology DepartmentUniversity of GlasgowGlasgow(Scotland)

Personalised recommendations