Experientia

, Volume 34, Issue 9, pp 1159–1161 | Cite as

Inhibition of vitamin A action in rat bone cultures by inhibitors of RNA and protein synthesis

  • A. Kistler
Article

Summary

Using explanted humeri of late fetal rats, retinoic acid induced a dose- and time-dependent regression of cartilage. The retinoic acid-induced release of proteoglycan into the medium was blocked by inhibitors of RNA and protein synthesis, suggesting its dependence upon continuous RNA and protein synthesis.

Keywords

Protein Synthesis Retinoic Acid Bone Culture 

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Copyright information

© Birkhäuser Verlag 1977

Authors and Affiliations

  • A. Kistler
    • 1
  1. 1.Biological Pharmaceutical Research DepartmentF. Hoffmann-La Roche & Co. LtdBasle(Switzerland)

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