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The effect of imipramine and nialamide on the accumulation of serotonin in snail (Helix pomatia) nervous tissue

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Zusammenfassung

Sowohl Nervengewebe als auch definierte Nervenzellsomata (GSC) vonHelix pomatia können zwar14C-Serotonin aufnehmen, aber nur im Nervengewebe wird es zu14C-Hydroxyindolessigsäure umgewandelt. Die Wirkung von Imipramin und Nialamid macht wahrscheinlich, dass Serotonin auf zwei Wegen inaktiviert wird, d. h. durch enzymatische Oxydation und durch Wiederaufnahme in die synaptischen Boutons.

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Authors and Affiliations

  1. Arbeitsgruppe Neurochemie, Max-Planck-Institut für experimentelle Medizin, D-3400, Göttingen, Germany

    N. N. Osborne, E. Priggemeier & V. Neuhoff

Authors
  1. N. N. Osborne
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  2. E. Priggemeier
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  3. V. Neuhoff
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Additional information

We acknowledge the financial support from the Deutsche Forschungsgemeinschaft (SFB 33) and Dr.B. Leonard for comments on the manuscript.

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Osborne, N.N., Priggemeier, E. & Neuhoff, V. The effect of imipramine and nialamide on the accumulation of serotonin in snail (Helix pomatia) nervous tissue. Experientia 29, 1351–1352 (1973). https://doi.org/10.1007/BF01922811

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