Skip to main content
SpringerLink
Log in

Kinetic characterization of acetylcholinesterase of muscle and rat brain

  • Specialia
  • Published:
Experientia Aims and scope Submit manuscript

Résumé

La présente étude a rélévé chez le rat des différences entre l'AChE du cerveau et celle du muscle, en ce qui concerne les pH optima, la température d'inactivation, le Km, les courbes de saturation et la réponse aux inhibiteurs. L'existence de sites allostériques différents dans l'enzyme des deux organes a aussi été observée. L'auteur suggère que ces propriétés cinétiques distinctes tiennent, en partie du moins, à des différences histophysiologiques entre les synapses de ces deux tissus.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  1. B. Katz,Nerve, Muscle and Synapse (McGraw-Hill, New York 1966), p. 143.

    Google Scholar 

  2. J. R. Williamson, J. B. Clark, W. J. Nicklas andB. Safer,Ion Homeostasis and Brain (Eds.B. K. Siesjö andS. C. Sørensen; Academic Press, New York 1971), p. 381.

    Google Scholar 

  3. K. D. Barron andJ. Bernsohn, J. Neurochem.15, 273 (1968).

    Article  CAS  PubMed  Google Scholar 

  4. G. L. Ellman, K. D. Courtney, V. Andres Jr. andR. M. Featherstone, Biochem. Pharmac.7, 88 (1961).

    Article  CAS  Google Scholar 

  5. O. H. Lowry, N. J. Rosebrough, A. L. Farr andR. J. Randall, J. biol. Chem.193, 265 (1951).

    Article  CAS  PubMed  Google Scholar 

  6. R. L. Jackson andM. A. Aprison, J. Neurochem.13, 1367 (1966).

    Article  CAS  PubMed  Google Scholar 

  7. H. D. Crone, J. Neurochem. 18, 489 (1971).

    Article  CAS  PubMed  Google Scholar 

  8. K. Ho andG. L. Ellman, J. Neurochem.16, 1505 (1969).

    Article  CAS  PubMed  Google Scholar 

  9. J. Massoulié andF. Rieger, Eur. J. Biochem.14, 430 (1970).

    Article  PubMed  Google Scholar 

  10. D. Nachmansohn, Science168, 1059 (1970).

    Article  CAS  PubMed  Google Scholar 

  11. J. P. Changeux, Molec. Pharmac.2, 369 (1966).

    CAS  Google Scholar 

  12. G. Kato, E. Tan andJ. Yung, Nature, Lond.236 N B, 185 (1972).

    Google Scholar 

  13. R. W. Olsen, J. C. Meunier andJ. P. Changeux, Febs Lett.28, 96 (1972).

    Article  CAS  PubMed  Google Scholar 

  14. G. Koelle,The Pharmacological Basis of Therapeutics (Eds.L. S. Goodman andA. Gilman; MacMillan, New York 1970), p. 603.

    Google Scholar 

  15. J. Kehoe, J. Physiol., Lond.225, 115 (1972).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Central Institute for Brain Research, Ijdijk 28, Amsterdam-0, The Netherlands

    J. M. Varela

Authors
  1. J. M. Varela
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Varela, J.M. Kinetic characterization of acetylcholinesterase of muscle and rat brain. Experientia 29, 1347–1349 (1973). https://doi.org/10.1007/BF01922809

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01922809

Keywords

Search

Navigation