Advertisement

Experientia

, Volume 31, Issue 3, pp 328–330 | Cite as

Lysergic acid diethylamide affects blood flow to specific areas of the conscious rat brain

  • H. Goldman
  • R. Fischer
  • N. Nicolov
  • S. Murphy
Specialia

Keywords

Blood Flow Specific Area Lysergic Acid Diethylamide Lysergic Acid Diethylamide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Zusammenfassung

Die i.v. Verabreichung von LSD an Ratten steigert den Blutkreislauf im Hirnstamm sowie im frontalen und parietalen Cortex selektiv. Es wurden durch 6-Nor-LSD, 2-Methyl-LSD undΔ8, 9-LSD weder wahrnehmbare Verhaltensänderungen noch Änderungen des regionalen Blutkreislaufs verursacht.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    S. H. Snyder andM. Reivich, Nature, Lond.209, 1093 (1966).Google Scholar
  2. 2.
    I. M. Diab, D. X. Freedman andL. J. Roth, Science173, 1022 (1971).PubMedGoogle Scholar
  3. 3.
    S. Feitelberg andH. Lampl, Arch. exp. Path. Pharmak.177, 726 (1935).CrossRefGoogle Scholar
  4. 4.
    H. M. Serota andR. W. Gerard, J. Neurophysiol.1, 115 (1938).Google Scholar
  5. 5.
    L. Sokoloff,Regional Neurochemistry (Pergamon, New York, 1967), p. 107.Google Scholar
  6. 6.
    N. A. Lassen, Physiol. Rev.39, 183 (1959).PubMedGoogle Scholar
  7. 7.
    L. J. Roth andC. F. Barlow, Science134, 22 (1961).PubMedGoogle Scholar
  8. 8.
    D. H. Ingvar, Acta neurol. scand.49, 233 (1973).PubMedGoogle Scholar
  9. 9.
    H. Goldman andL. A. Sapirstein, Am. J. Physiol.224, 122 (1973).PubMedGoogle Scholar
  10. 10.
    L. Sokoloff, S. Perlin, C. Kornetsky andS. S. Kety, Ann. N. Y. Acad. Sci.66, 468 (1957).PubMedGoogle Scholar
  11. 11.
    D. H. Ingvar andU. Soderberg, Experientia12, 427 (1957).Google Scholar
  12. 12.
    N. J. Giarman,LSD, Man and Society (Weslyan, Middletown, Conn. 1967), p. 143.Google Scholar
  13. 13.
    Acknowledgements: We are especially grateful to Drs.Albert Hofman andAurelio Cerletti (Sandoz, Basel) for the gifts of LSD derivatives. This investigation was supported by Public Health Service Grant No. NS-05526 from the National Institute of Neurological Diseases and Stroke.Google Scholar

Copyright information

© Birkhäuser Verlag 1975

Authors and Affiliations

  • H. Goldman
    • 1
  • R. Fischer
    • 1
  • N. Nicolov
    • 1
  • S. Murphy
    • 1
  1. 1.Department of PharmacologyWayne State University School of MedicineDetroitUSA

Personalised recommendations