, Volume 47, Issue 8, pp 838–841 | Cite as

Distribution of the 1,25 dihydroxy-vitamin D3 receptor in the bursa of Fabricius of chicken

  • M. Petrini
  • F. Bianchi
  • A. Dolfi
  • M. Lupetti
Research Articles


The vitamin D3 metabolite 1,25(OH)2D3 is probably involved in B lymphocyte ontogeny. We therefore determined the distribution of the 1,25(OH)2D3 receptor in the bursa of Fabricius and spleen cells of 7-day-old chicks, by immunohistochemistry using a monoclonal antibody against the chick intestinal cell 1,25(OH)2D3 receptor. The bursa cells of young (7-day-old) chicks contained large amounts of receptor while the spleen cells did not. The bursa cells of older (35-day-old) chicks contained fewer receptors, but the number of receptors in the spleen increased.

Key words

Vitamin D3 receptor dihydroxy-vitamin D3 bursa of Fabricius ontogeny of immune system B lymphocytes 


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Copyright information

© Birkhäuser Verlag 1991

Authors and Affiliations

  • M. Petrini
    • 2
  • F. Bianchi
    • 1
  • A. Dolfi
    • 1
  • M. Lupetti
    • 1
  1. 1.Chair of Histology and Embryology, Faculty of MedicineUniversity of PisaPisa(Italy)
  2. 2.Institute of Medical Clinic I, and Institute of AnatomyUniversity of PisaPisa(Italy)

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