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Bicarbonate and chloride transport across rat ileal basolateral membrane

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Abstract

The mechanisms of HCO −3 and Cl− transport across basolateral membranes from rat ileum were investigated in isolated vesicles by means of uptake experiments. Neither Cl−/HCO −3 exchanger nor Na+−(HCO −3 )n cotransport seem to be present in ileal basolateral membranes. Moreover Cl− uptake is unaffected bycis Na+ and/or K+ gradients, indicating the absence of Na+−Cl−, K+−Cl− and Na+−K+−2Cl− symport activity. An electrically conductive pathway seems to be responsible for both HCO −3 and Cl− fluxes. Evidence is also given for the presence of a Na+/H+ exchanger at the basolateral pole of ileal enterocytes.

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Authors and Affiliations

  1. Dipartimento di Fisiologia e Biochimica Generali, Università di Milano, via Celoria 26, I-20133, Milano, Italy

    M. Tosco, M. N. Orsenigo & A. Faelli

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  1. M. Tosco
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  2. M. N. Orsenigo
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  3. A. Faelli
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Tosco, M., Orsenigo, M.N. & Faelli, A. Bicarbonate and chloride transport across rat ileal basolateral membrane. Experientia 51, 799–803 (1995). https://doi.org/10.1007/BF01922433

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  • DOI: https://doi.org/10.1007/BF01922433

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