Abstract
Acylfulvene, derived from the sesquiterpene illudin S by treatment with acid (reverse Prins reaction), is far less reactive to thiols than illudin S. However, it is reduced readily to an aromatic product, in the same way as illudin S. This may explain its greatly improved therapeutic index compared to that of the parent compound.
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McMorris, T.C., Kelner, M.J., Wang, W. et al. Acylfulvenes, a new class of potent antitumor agents. Experientia 52, 75–80 (1996). https://doi.org/10.1007/BF01922420
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DOI: https://doi.org/10.1007/BF01922420