Experientia

, Volume 33, Issue 9, pp 1231–1233 | Cite as

The sensitivity to plasmin digestion of human IgG proteins of different heavy chain subclasses

  • G. Virella
  • Chang-Jing G. Yeh
Haemotologica, Immunologica

Summary

Normal IgG and purified IgG proteins of all 4 subclasses were digested with plasmin. As expected, IgG3 proteins were highly susceptible to degradation. Usually, activation with streptokinase resulted in faster and more accentuated degradation, but normal IgG was more intensely degraded by nonactivated plasmin. The presence of plasmin activators in IgG preparations might account for this observation.

Keywords

Heavy Chain Streptokinase Plasmin Plasmin Activator Heavy Chain Subclass 

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Copyright information

© Birkhäuser Verlag 1977

Authors and Affiliations

  • G. Virella
    • 1
  • Chang-Jing G. Yeh
    • 1
  1. 1.Department of Basic and Clinical Immunology and MicrobiologyMedical University of South CarolinaCharlestonUSA

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