, Volume 33, Issue 9, pp 1212–1213 | Cite as

Effects of the antibiotic netropsin on mouse ascites tumour chromosomes in vitro

  • Anna M. Wobus
  • U. Wobus
  • J. Schöneich
Anatomica, Histologica, Embryologica, Carcinologica


The antibiotic netropsin was found to induce an increase of the aberration frequency of up to 10% and a decondensation and elongation of centromeric regions of the chromosomes in mouse ascites tumour cells cultivated in vitro.


Tumour Cell Centromeric Region Ascites Tumour Aberration Frequency Mouse Ascites 
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  1. 2.
    C. Zimmer, Progr. nucl. Acid Res. molec. Biol.15, 285 (1975).Google Scholar
  2. 3.
    F. E. Hahn, in: Antibiotics, vol. 3. Ed. J. W. Corcoran and F. E. Hahn, Springer-Verlag, Berlin and New York 1974.Google Scholar
  3. 4.
    E. Negelein, I. Leistner und L. Jähnchen, Acta biol. med. germ.16, 372 (1966).PubMedGoogle Scholar
  4. 5.
    A. M. Wobus und J. Schöneich, Pharmazie32, 178 (1977).PubMedGoogle Scholar
  5. 6.
    R. Thieme, Diploma thesis, Halle 1975.Google Scholar
  6. 7.
    V. Fucik, A. Michaelis and R. Rieger, Mutation Res.9, 599 (1970).PubMedGoogle Scholar
  7. 8.
    T. C. Hsu, S. Pathak and D. A. Shafer, Exp. Cell Res.79, 484 (1973).PubMedGoogle Scholar
  8. 9.
    M. L. Pardue and J. G. Gall, Science168, 1356 (1970).PubMedGoogle Scholar
  9. 10.
    K. W. Jones, Nature225, 912 (1970).PubMedGoogle Scholar
  10. 11.
    P. A. Biro, A. Carr-Brown, E. M. Southern and P. M. B. Walker, J. molec. Biol.94, 71 (1975).PubMedGoogle Scholar
  11. 12.
    C. Zimmer, G. Luck and J. Frick, Nucl. Acids Res.3, 1521 (1976).PubMedGoogle Scholar
  12. 13.
    J. D. McGhee, Biopolymers15, 1345 (1976).PubMedGoogle Scholar
  13. 14.
    C. Zimmer, G. Luck and E. Sarfert, Biol. Zbl.95, 157 (1976).Google Scholar
  14. 15.
    J. Hilwig and A. Gropp, Exp. Cell Res.81, 474 (1973).PubMedGoogle Scholar
  15. 16.
    M. A. Kim and K. H. Grzeschik, Exp. Cell Res.88, 406 (1974).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1977

Authors and Affiliations

  • Anna M. Wobus
    • 1
  • U. Wobus
    • 1
  • J. Schöneich
    • 1
  1. 1.Zentralinstitut für Genetik und Kulturpflanzenforschung der Akademie der Wissenschaften der DDRGatersleben(German Democratic Republic)

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