Skip to main content
SpringerLink
Log in

A cannabinoid with cardiovascular activity but no overt behavioral effects

Experientia volume 33, pages 1204–1205 (1977)Cite this article

Summary

Abnormal-Δ8-tetrahydrocannabidiol (ABN-Δ8-THC) failed to elicit central nervous system and cardiovascular effects in laboratory animals. Abnormal-cannabidiol (ABN-CBD) was also devoid of overt behavioral effects but produced marked hypotension with only slight bradycardia in anesthesized dogs.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

USD 39.95

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

References

  1. R. Mechoulam, N. K. McCallum and S. Burstein, Chem. Rev.76, 75 (1976).

    Article  CAS  Google Scholar 

  2. R. K. Razdan, H. C. Dalzell and G. R. Handrick, J. Am. Chem. Soc.96, 5860 (1974).

    Article  CAS  PubMed  Google Scholar 

  3. T. Petrizilka, W. Haefligen and C. Sikemeier, Helv. Chim. Acta52, 1102 (1969).

    Article  Google Scholar 

  4. B. R. Martin, W. L. Dewey, L. S. Harris and J. Beckner, Pharmac. Biochem. Behav.3, 849 (1975).

    Article  CAS  Google Scholar 

  5. J. C. Cradock, J. P. Davignon, C. L. Sitherst and A. M. Guarino, J. Pharm. Pharmac.25, 345 (1973).

    Article  CAS  Google Scholar 

  6. D. Holtzman, R. A. Lovell, J. H. Jaffe and D. X. Freedman, Science163, 1464 (1969).

    Article  CAS  PubMed  Google Scholar 

  7. M. D. Brannan, J. D. Proctor and A. J. Wasserman, Fedn Proc.34, 744 (1975).

    Google Scholar 

  8. R. P. Walton, L. F. Martin and J. H. Keller, J. Pharmac. exp. Ther.62, 239 (1938).

    CAS  Google Scholar 

  9. H. F. Hardman, E. F. Domino and M. H. Seevers, Clearinghouse for Federal Scientific and technical Information, AD 707-699, p. 1 (1957).

  10. H. F. Hardman, E. F. Domino and M. H. Seevers, Pharmac. Rev.23, 295 (1971).

    CAS  Google Scholar 

  11. W. L. Dewey, L. S. Harris, J. F. Howes, J. S. Kennedy, F. E. Granchelli, H. G. Pars and R. K. Razdan, Nature, Lond.226, 1265 (1970).

    Article  CAS  PubMed  Google Scholar 

  12. M. Perez-Reyes, D. Wagner, M. E. Wall and K. H. Davis, in: Pharmacology of Marihuana, p. 829. Ed. M. C. Braude and S. Szara. Raven Press, New York 1976.

    Google Scholar 

  13. R. R. Vollmer, I. Cavero, R. J. Ertel, T. A. Solomon and J. P. Buckley, J. Pharm. Pharmac.26, 186 (1974).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, Medical College of Virginia, 23298, Richmond, Virginia, USA

    M. D. Adams, J. T. Earnhardt, B. R. Martin, L. S. Harris & W. L. Dewey

  2. Sheehan Institute for Research, Inc., 02138, Cambridge, Massachusetts, USA

    M. D. Adams, J. T. Earnhardt, B. R. Martin, L. S. Harris, W. L. Dewey & R. K. Razdan

Authors
  1. M. D. Adams
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. T. Earnhardt
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. R. Martin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. L. S. Harris
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. W. L. Dewey
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. R. K. Razdan
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Acknowledgment. This work was supported by NIDA (grant No. DA-00574-01 and DA-00490) and Virginia Heart Society (grant No. RR-05697)

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Adams, M.D., Earnhardt, J.T., Martin, B.R. et al. A cannabinoid with cardiovascular activity but no overt behavioral effects. Experientia 33, 1204–1205 (1977). https://doi.org/10.1007/BF01922330

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01922330

Keywords

search

Navigation