Abnormal-Δ8-tetrahydrocannabidiol (ABN-Δ8-THC) failed to elicit central nervous system and cardiovascular effects in laboratory animals. Abnormal-cannabidiol (ABN-CBD) was also devoid of overt behavioral effects but produced marked hypotension with only slight bradycardia in anesthesized dogs.
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Acknowledgment. This work was supported by NIDA (grant No. DA-00574-01 and DA-00490) and Virginia Heart Society (grant No. RR-05697)
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Adams, M.D., Earnhardt, J.T., Martin, B.R. et al. A cannabinoid with cardiovascular activity but no overt behavioral effects. Experientia 33, 1204–1205 (1977). https://doi.org/10.1007/BF01922330