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Improved treatment of organophosphate intoxication by use of scopolamine or dexetimide

  • Pharmacologica
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Summary

Organophosphate intoxications have been treated by dexetimide plus obidoxime. Rabbits intoxicated by the 50-80fold LD50 of different organophosphates survived. Prophylactic application of dexetimide or scopolamine plus obidoxime increased the LD50 of DFP by a factor up to 180.

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Authors and Affiliations

  1. Department of Pharmacology, University of Kiel, Hospitalstrasse, 4-6, D-2300, Kiel, Germany

    U. Bertram, A. Kasten, H. Lüllmann & A. Ziegler

Authors
  1. U. Bertram
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  2. A. Kasten
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  3. H. Lüllmann
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  4. A. Ziegler
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Additional information

Supported by the Fraunhofer-Gesellschaft e. V., Munich, BRD

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Bertram, U., Kasten, A., Lüllmann, H. et al. Improved treatment of organophosphate intoxication by use of scopolamine or dexetimide. Experientia 33, 1196–1197 (1977). https://doi.org/10.1007/BF01922324

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  • DOI: https://doi.org/10.1007/BF01922324

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