Summary
Sr action potentials elicited in guinea-pig papillary muscle under Na-free conditions decreased the space constant and increased the input resistance. It suggests that Sr current induced intercellular uncoupling by increasing [Sr]i.
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Composition of the normal Tyrode was: NaCl 142, KCl 2.7, CaCl2 1.8, MgCl2 1, Tris-HCl 10, glucose 5 (mM); pH 7.3. That of Sr-Tyrode was: SrCl2 20, choline chloride 115, KCl 2.7, Tris-HCl 10, glucose 5 (mM); pH 7.3.
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Supported by grant from Japanese Ministry of Education and from Japan Heart Foundation Research Grant for 1976 contributed by Tokyo Marine and Fire Insurance Co., Ltd.
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Ochi, R. Electrical uncoupling by Sr action potentials in cardiac muscle. Experientia 33, 1187–1189 (1977). https://doi.org/10.1007/BF01922319
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DOI: https://doi.org/10.1007/BF01922319