Summary
Cadmium chloride injected to mice (20 μmoles/kg) provokes in the livers a degradation of polyribosomes and diminishes their protein synthetic ability measured in vitro. CdCl2 added in a final concentrations between 30 and 100 μM to the protein synthetic cell-free system derived from livers of control mice inhibits its activity.
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H. M. Perry, Jr., G. S. Thind and E. F. Perry, Med. Clin. N. Am.60, 759 (1976).
M. Webb, Br. med. Bull.31, 246 (1976).
G. C. Becking, Med. Clins N. Am.60, 813 (1976).
K. S. Squibb and R. J. Cousins, Envir. Physiol. Biochem.4, 24 (1974).
S. E. Bryan and H. A. Hidalgo, Biochem. biophys. Res. Commun.68, 858 (1976).
H. A. Hidalgo, V. Koppy and S. E. Bryan, FEBS Lett.64, 159 (1976).
R. E. Stoll, J. F. White, T. S. Miya and W. F. Bousquet, Toxic. appl. Pharmac.37, 61 (1976).
G. Vassart, J. E. Dumont and F. R. L. Cantraine, Biochim. biophys. Acta247, 471 (1971).
S. Gamulin, C. H. Gray and M. R. Norman, Biochim. biophys. Acta259, 239 (1972).
H. Noll, in: Techniques in protein biosynthesis, vol. 2, p. 101. Academic Press, London and New York 1969.
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Acknowledgments. We are grateful to Prof. P. Sokolić for helpful discussion. The work was supported by Wellcome Trust grant and by a gift of chemicals from Kemika, Zagreb. We are grateful to both these organizations.
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Gamulin, S., Car, N. & Narancsik, P. Effect of cadmium on polyribosome structure and function in mouse liver. Experientia 33, 1144–1145 (1977). https://doi.org/10.1007/BF01922292
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DOI: https://doi.org/10.1007/BF01922292