Skip to main content
SpringerLink
Log in

Reduction of aflatoxin B1 with zinc borohydride: An efficient preparation of aflatoxicol

  • Specialia
  • Chimica, Biochimica
  • Published:
Experientia Aims and scope Submit manuscript

Summary

A simple and mild reduction of aflatoxin B1, involving treatment of aflatoxin B1 with ethereal zinc borohydride to give 57–65% yield of diastereomeric aflatoxicols, is described.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. T. C. Campbell and J. R. Hayes, Toxic. appl. Pharmac.35, 199 (1976).

    Article  CAS  Google Scholar 

  2. R. W. Detroy and C. W. Hesseltine, Can. J. Biochem.48, 830 (1970).

    Article  CAS  PubMed  Google Scholar 

  3. J. A. Robertson, D. J. Teunisson and G. J. Boudreaux, J. agric. Fd Chem.18, 1090 (1970).

    Article  CAS  Google Scholar 

  4. D. S. P. Patterson and B. A. Roberts, Fd Cosmet. Toxic.10, 501 (1972).

    Article  CAS  Google Scholar 

  5. R. C. Garner, E. C. Miller and J. A. Miller, Cancer Res.32, 2058 (1972).

    CAS  PubMed  Google Scholar 

  6. P. Crabbe, G. A. Garcia and C. Rius, J. chem. Soc., Perkin I, 810 (1973).

    Article  Google Scholar 

  7. F. S. Chu, J. Ass. off. analyt. Chem.54, 1304 (1971).

    CAS  Google Scholar 

  8. W. J. Gansler, F. Johnson and A. D. B. Sloan, J. Am. Chem. Soc.82, 6074 (1960).

    Article  Google Scholar 

  9. G. A. Bray, Analyt. Biochem.1, 279 (1960).

    Article  CAS  Google Scholar 

  10. S. H. Ashoor and F. S. Chu, J. Ass. off. analyt. Chem.58, 492 (1975).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Food Research Institute and Department of Food Microbiology and Toxicology, University of Wisconsin, 53706, Madison, Wisconsin, USA

    M. -T. Stephen Hsia & F. S. Chu

Authors
  1. M. -T. Stephen Hsia
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. S. Chu
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This work was supported by the College of Agricultural and Life Sciences, the University of Wisconsin, Madison, and by Public Health Service Research, grant No. CA 15064, from the National Cancer Institute, and by funds from contributions of food industries to the Food Research Institute. We are grateful to Professor Dennis Hsieh for a gift of natural aflatoxicol, to Mr William Harder for technical assistance throughout this investigation, and to Mr Gary Girdaukas for taking mass spectra.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Stephen Hsia, M.T., Chu, F.S. Reduction of aflatoxin B1 with zinc borohydride: An efficient preparation of aflatoxicol. Experientia 33, 1132–1133 (1977). https://doi.org/10.1007/BF01922282

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01922282

Keywords

Search

Navigation