, Volume 33, Issue 4, pp 531–533 | Cite as

Suppression of the secondary immune response by specific antibody, when given together with the secondary antigenic stimulus

  • H. Finger
  • H. Hof
  • C.-H. Wirsing
  • P. Emmerling


It is generally believed that antibody-mediated immunosuppression can be only produced in non-primed individuals, and that this applies both to experimental animals and Rh-negative women at risk. However, in this paper it is reported that the additional injection of 0.2 ml of an antiserum to sheep erythrocytes (SE) together with a secondary antigenic stimulus of 108 SE into mice, primarily immunized by a tiny dose of 5×105 SE 28 days before, was capable of producing effective suppression of the secondary immune response.


Immune Response Experimental Animal Specific Antibody Effective Suppression Sheep Erythrocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 3.
    J. W. Uhr and G. Möller, Adv. Immun.8, 81 (1968).PubMedGoogle Scholar
  2. 4.
    H. Wigzell, Cold Spring Harb. Symp. quant. Biol.32, 507 (1967).Google Scholar
  3. 5.
    H. Wigzell, Antibiot. Chemother.15, 82 (1969).PubMedGoogle Scholar
  4. 6.
    D. A. Rowley and F. W. Fitch, in: Regulation of Antibody Response, p. 127. Ed. B. Cinader, Ch. C. Thomas, Springfield, Ill. 1968).Google Scholar
  5. 7.
    A. Morris and G. Möller, J. Immun.101, 439 (1968).PubMedGoogle Scholar
  6. 8.
    J. Sterzl, D. Johanovska and J. Milerova, Folia microbiol., Praha14, 351 (1969).Google Scholar
  7. 9.
    P. Emmerling, H. Finger and L. Eisele, Z. med. Mikrobiol. Immun. 156, 70 (1970).Google Scholar
  8. 10.
    H. Finger, P. Emmerling and I. Fölmer, Z. ImmunForsch,142 468 (1972).Google Scholar
  9. 11.
    H. Finger and P. Emmerling, Z. ImmunForsch.145, 95 (1973).Google Scholar
  10. 12.
    V. J. Freda, J. G. Gormann and W. Pollack, Science151 828 (1966).Google Scholar
  11. 13.
    WHO-Report, Bull. Wld Hlth Org.36, 467 (1967).Google Scholar
  12. 14.
    H. Finger and P. Emmerling, Immun. Infekt.3, 3 (1975).PubMedGoogle Scholar
  13. 15.
    P. Hindemann, M. Hinselmann and P. Frey. Gynaecologia, Basel167, 275 (1969).Google Scholar
  14. 16.
    G. Schellong and J. Schneider, in: Blutgruppenkunde, p. 111. Ed. B. Urbaschek. Die medizinische Verlagsgesellschaft, Marburg 1973.Google Scholar
  15. 17.
    J. Schneider, Dt. Med. Wschr.101, 596 (1976).Google Scholar
  16. 18.
    D. Samson and P. L. Mollison, Immunology28, 349 (1975).PubMedGoogle Scholar
  17. 19.
    H. Finger, P. Emmerling and E. Brüss, Can. J. Microbiol.15, 816 (1969).Google Scholar
  18. 20.
    N. K. Jerne, A. Nordin and C. Henry, in: Cell-Bond Antibodies, p. 109 Ed. B. Amos and H. Koprowski, Wistar Institute Press, Philadelphia 1963.Google Scholar
  19. 21.
    H. H. Wortis, R. B. Taylor and D. W. Dresser, Immunology11, 603 (1966).PubMedGoogle Scholar
  20. 22.
    H. Finger, P. Emmerling and E. Brüss, Infect. Immun.1, 251 (1970).Google Scholar
  21. 23.
    P. H. Plotz, N. Talal and R. Asofsky, J. Immun.100, 744 (1968).PubMedGoogle Scholar
  22. 24.
    G. Möller, Immunology17, 227 (1969).PubMedGoogle Scholar
  23. 25.
    G. W. Siskind and B. Benacerraf, Adv. Immun.10, 1 (1969).PubMedGoogle Scholar
  24. 26.
    A. M. C. Koros and E. C. Hamill, Immunology25, 717 (1973).PubMedGoogle Scholar
  25. 27.
    H. Finger and P. Emmerling, Dt. Med. Wschr.95, 1025 (1970).Google Scholar
  26. 28.
    H. H. Gunson, F. Stratton and P. K. Phillips, Br. J. Haemat.32, 317 (1976).Google Scholar
  27. 29.
    H. H. Gunson, F. Stratton and P. K. Phillips, Br. J. Haemat.32, 331 (1976).Google Scholar
  28. 30.
    P. L. Mollison, Br. J. Haemat.14, 1 (1968).Google Scholar
  29. 31.
    J. Schneider and O. Preisler, Blut12, 4 (1966).Google Scholar

Copyright information

© Birkhäuser Verlag 1977

Authors and Affiliations

  • H. Finger
    • 1
    • 2
  • H. Hof
    • 1
    • 2
  • C.-H. Wirsing
    • 1
    • 2
  • P. Emmerling
    • 1
    • 2
  1. 1.Institute of HygieneMunicipal Hospital of KrefeldKrefeld 1(Federal Republic of Germany)
  2. 2.Institute of Hygiene and MicrobiologyUniversity of WürzburgBRD

Personalised recommendations