, Volume 34, Issue 1, pp 85–86 | Cite as

Modification of hepatotoxic effects of aflatoxin B1 in rabbits by immunization

  • I. Ueno
  • F. S. Chu


Reduction of acute toxic effect of aflatoxin B1 was achieved by immunizing the rabbits with small amounts of bovine serum albumin-aflatoxin B1 conjugate. Rabbits after immunization showed lower mortality, near normal serum isocitric dehydrogenase activity, no abnormality in livers when challenged with a single dose of aflatoxin B1. The results suggest that immunization might be used prophylactically against aflatoxicosis.


Bovine Serum Single Dose Toxic Effect Aflatoxin Lower Mortality 
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  1. 4.
    L. A. Goldblatt, Aflatoxin—Scientific background, control and implications. Academic Press, New York 1969.Google Scholar
  2. 5.
    G. N. Wogan, A. Rev. Pharmac.15, 437 (1975).CrossRefGoogle Scholar
  3. 6.
    F. S. Chu, M. T. Stephen Hsia and Piera Sun, J. Ass. off. analyt. Chem.60, 791 (1977).Google Scholar
  4. 7.
    J. J. Langone and H. Van Vunakis, J. natl. Cancer Inst.56, 591 (1976).PubMedGoogle Scholar
  5. 8.
    F. S. Chu and I. Ueno, Appl. environ. Microbiol.33, 1125 (1977).PubMedGoogle Scholar
  6. 9.
    F. S. Chu, Fred C. C. Chang and R. D. Hinsdill, Appl. environ. Microbiol.31, 831 (1976).PubMedGoogle Scholar
  7. 10.
    E. Bernt and H. U. Bergmeyer, in: Methods of enzymatic analysis, p. 624. Ed. H. U. Bergmeyer. Academic Press, New York; and Sigma technical bulletin number 175/150.Google Scholar
  8. 11.
    R. M. Peck and E. B. Peck, Cancer Res.31, 1550 (1971).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1978

Authors and Affiliations

  • I. Ueno
    • 1
  • F. S. Chu
    • 1
  1. 1.Food Research Institute and Department of Food Microbiology and ToxicologyUniversity of WisconsinMadisonUSA

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