Modification of hepatotoxic effects of aflatoxin B1 in rabbits by immunization
Reduction of acute toxic effect of aflatoxin B1 was achieved by immunizing the rabbits with small amounts of bovine serum albumin-aflatoxin B1 conjugate. Rabbits after immunization showed lower mortality, near normal serum isocitric dehydrogenase activity, no abnormality in livers when challenged with a single dose of aflatoxin B1. The results suggest that immunization might be used prophylactically against aflatoxicosis.
KeywordsBovine Serum Single Dose Toxic Effect Aflatoxin Lower Mortality
- 4.L. A. Goldblatt, Aflatoxin—Scientific background, control and implications. Academic Press, New York 1969.Google Scholar
- 6.F. S. Chu, M. T. Stephen Hsia and Piera Sun, J. Ass. off. analyt. Chem.60, 791 (1977).Google Scholar
- 10.E. Bernt and H. U. Bergmeyer, in: Methods of enzymatic analysis, p. 624. Ed. H. U. Bergmeyer. Academic Press, New York; and Sigma technical bulletin number 175/150.Google Scholar