Modification of hepatotoxic effects of aflatoxin B1 in rabbits by immunization
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Reduction of acute toxic effect of aflatoxin B1 was achieved by immunizing the rabbits with small amounts of bovine serum albumin-aflatoxin B1 conjugate. Rabbits after immunization showed lower mortality, near normal serum isocitric dehydrogenase activity, no abnormality in livers when challenged with a single dose of aflatoxin B1. The results suggest that immunization might be used prophylactically against aflatoxicosis.
KeywordsBovine Serum Single Dose Toxic Effect Aflatoxin Lower Mortality
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