Abstract
Pentoxifylline (PTX), a methylxanthine derivative, effectively prevents acute lung injury in different animal models. To investigate whether PTX would attenuate acute lung injury induced by microemboli resulting from treatment with calcium chloride (CaCl2) suspension, an isolated blood-perfused rat lung model was used. Pretreatment with PTX prevented the increase in pulmonary arterial pressure (PAP), lung weight gain and protein concentration in the lavage fluid after CaCl2 treatment.
Similar content being viewed by others
References
Dettelbach, H. R., and Aviado, D. M., J. clin. Pharmac.25 (1985) 8.
Porter, J. M., Cutler, B. S., Lee, B. Y., Reich, T., Reichle, F. A., Scogin, J. T., and Strandness, D. E., Am. Heart J.104 (1982) 66.
Mandell, G. L., Am. Rev. resp. Dis.138 (1988) 1103.
Stelzner, T. J., Weil, J. V., and O'Brien, R. F., J. cell. comp. Physiol.139 (1989) 157.
Bessler, H., Gilgal, R., Djaldetti, M., and Zahavi, I., J. Leukocyte Biol.40 (1986) 474.
Ishizaka, A., Wu, Z., Stephens, K. E., Havada, H., Hogue, R. S., O'Hanley, P. T., and Raffin, T. A., Am. Rev. resp. Dis.138 (1988) 376.
Lilly, C. M., Sandhu, J. S., Ishizaka, A., Havader, H., Yonemaru, M., Larrick, J. W., Shi, T. X., O'Hanley, P. T., and Raffin, T. A., Am. Rev. resp. Dis.137 (1989) 1364.
Lin, H. I., Hsu, K., Yan, H. C., and Shen, C. Y., J. Formosan med. Ass.89 (1990) 742.
Hsu, K., Wang, D., Shen, C. Y., and Ching, C. Y., Proc. natl. Sci. Coun. B.17 (1993) 57.
Welsh, C. H., Lien, D., Worthen, G. S., and Weil, J. V., Am. Rev. resp. Dis.138 (1988) 1106.
Bertocchi, F., Proserpio, P., and Dejana, E., in: PTX and Luekocyte Function, p. 68. Eds G. Mandell and W. J. Novik. Somerville 1988.
Till, G. O., Warren, J. S., and Gannon, D. E., in: PTX and Leukocyte Function, p. 124. Eds G. Mandell and W. J. Novik. Somerville 1988.
Hsu, K., Wang, D., Shen, C. Y., and Chiang, C. H., J. Formosan med. Ass.91 (1992) 955.
Brandford, M. M., Analyt. Biochem.72 (1976) 748.
Schneider, R. C., Zapol, W. M., and Carvalho, A. C., Am. Rev. resp. Dis.122 (1980) 445.
Orell, S. R., Acta. path. microbiol. scand.79 (1971) 65.
Hill, R. N., Shibel, E. M., and Spragg, R. G., Trans. Am. Soc. artif. internal Organs21 (1975) 199.
Heckman, H. B., Lonergan, E. A., Staunton, H. P. B., Dennis, R. C., and Shepro, D., Surgery83 (1978) 277.
King, E. G., Weilly, H. S., Genton, E., and Ashbaugh, D. G., Surgery69 (1971) 533.
Spragg, R. G., Abraham, J. L., and Loomis, W. H., Am. Rev. resp. Dis.126 (1982) 553.
Almquist, P., Kucnzig, M., and Schwatz, S. I., J. Trauma23 (1983) 405.
Heffner, J. E., Sahn, S. A., and Repine, J. E., Am. Rev. resp. Dis.135 (1987) 482.
Wang, D., Chou, C. L., Hsu, K., and Chen, H. I., J. appl. Physiol.70 (1991) 2417.
Graham, F. L., and Van Der Eb, A. J., Virology52 (1973) 456.
Hoffman, H., Hatherill, J. R., Crowley, J., Harada, H., Yonemaru, M., Zheng, H., Ishizaka, A., and Raffin, T. A., Am. Rev. resp. Dis.143 (1991) 289.
Harada, H., Ishizaka, A., Yonemaru, M., Mallick, A. A., Hatherill, J. R., Zheng, H., Lilly, C. M., O'Hanley, P. T., and Raffin, T. A., Am. Rev. resp. Dis.140 (1989) 974.
McDonald, R. J., Am. Rev. resp. Dis.144 (1991) 347.
Yonemaru, M., Hatherill, Y. R., Hoffmann, H., Zheng, H., Ishii, K., and Raffin, T. A., J. appl. Physiol.71 (1991) 342.
Sato, K., Stelzner, T. J., O'Brien, R. F., Wesil, J. V., and Weilsh, C. H., Am. J. resp. Cell molec. Biol.4 (1991) 219.
Farber, H. W., Fairman, R. P., Millan, J. E., Rounds, S., and Glauser, F. L. Am. J. resp. Cell molec. Biol.1 (1989) 27.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Shen, C.Y., Hsu, K., Wang, D. et al. Pentoxifylline attenuates acute lung injury induced by microemboli. Experientia 51, 956–960 (1995). https://doi.org/10.1007/BF01921747
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01921747