Experientia

, Volume 51, Issue 9–10, pp 941–944 | Cite as

The influence of prostacyclin (PGI2) on contractile properties of isolated right ventricle of rat heart

  • M. Pavlović
  • D. Petković
  • M. Cvetković
  • D. J. Macut
  • K. Zdjelar
  • M. Nešić
  • O. Bosnić
  • R. Radulović
  • M. Mihajlović
Research Articles

Abstract

The mechanism of the positive inotropic effect of prostacyclin (PGI2) (2.6×10−6 mol/l) on the isolated right ventricle of rat heart was studied. Our results show that the positive inotropic effect of prostacyclin is produced indirectly through beta adrenoceptors and slow Ca2+ channels, because blockade of slow Ca2+ channels with verapamil (10−6 mol/l) and beta adrenoceptors with propranolol (10−6 mol/l) abolishes this effect. Alpha adrenoceptors do not mediate the action of PGI2.

Key words

Prostacyclin propranolol verapamil right ventricle inotropic effect 

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Copyright information

© Birkhäuser Verlag Basel 1995

Authors and Affiliations

  • M. Pavlović
    • 1
  • D. Petković
    • 1
  • M. Cvetković
    • 1
  • D. J. Macut
    • 1
  • K. Zdjelar
    • 1
  • M. Nešić
    • 1
  • O. Bosnić
    • 1
  • R. Radulović
    • 1
  • M. Mihajlović
    • 1
  1. 1.Institute of Physiology, Faculty of MedicineUniversity of BelgradeBelgrade(Yugoslavia)

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