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Über den Einfluss der Kettenlänge bei C-terminalen Sequenzen der Substanz P — in Vergleich mit analogen Physalaemin- und Eledoisin-Peptiden—auf die Wirksamkeit am Meerschweinchen-Ileum

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Summary

Substance Phas been synthesized by stepwise coupling of trichlorophenyl esters or mixed anhydrides of Boc- or Bpoc-protected amino acids. In the guinea-pig ileum the contractions of N-terminal shortened substance P peptides are estimated and discussed in relation to the chain length. The octapeptide is the most effective, similar to what is known of eledosin and physalaemin C-terminal sequences.

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References

  1. U. S. v. Euler undJ. H. Gaddum, J. Physiol., London.72, 74 (1931).

    Article  Google Scholar 

  2. K. Vogler, W. Haefely, A. Hürlimann, R. O. Studer, W. Lergier, R. Strässle undK. H. Berneis, Ann. N.Y. Acad. Sci.104, 378 (1963).

    Article  CAS  Google Scholar 

  3. R. A. Boissonnas, J. Franz undE. Stürmer, Ann. N. Y. Acad. Sci.104, 376 (1963).

    Article  CAS  Google Scholar 

  4. H. Zuber, Ann. N.Y. Acad. Sci.104, 391 (1963).

    Article  CAS  Google Scholar 

  5. F. Lembeck undK. Starke, Naunyn-Schmiedebergs Arch. Pharmak. exp. Path.259, 375 (1968).

    Article  CAS  Google Scholar 

  6. M. M. Chang undS. E. Leeman, J. biol. Chem.245, 4784 (1970).

    Article  CAS  Google Scholar 

  7. M. M. Chang, S. E. Leeman andH. D. Niall, Nature New Biol.232, 86 (1971).

    Article  CAS  Google Scholar 

  8. G. W. Treagar, H. D. Niall, J. T. Potts Jr., S. E. Leeman undM. M. Chang, Nature New Biol.232, 87 (1971).

    Article  Google Scholar 

  9. R. O. Studer, A. Trzeciak undW. Lergier, Helv. chim. Acta56, 860 (1973).

    Article  CAS  Google Scholar 

  10. V. Erspamer undA. Anastasi, Experientia18, 58 (1962).

    Article  CAS  Google Scholar 

  11. V. Erspamer, A. Anastasi, B. Bertaccini undJ. M. Cei, Experientia20, 489 (1964).

    Article  CAS  Google Scholar 

  12. K. Lübke, R. Hempel undE. Schröder, Experientia21, 84 (1965).

    Article  Google Scholar 

  13. L. Bernardi, G. Bosisio, F. Chllemi, G. de Caro, R. de Castiglione, R. Erspamer, Al. Glaesser undO. Goffredo, Experientia22, 29 (1966).

    Article  CAS  Google Scholar 

  14. P. Oehme, J. Bergmann, H. G. Müller, R. Grupe, H. Niedrich, W. E. Vogt undF. Jung, Acta biol. med. germ.28, 121 (1972).

    CAS  Google Scholar 

  15. E. Schröder undK. Lübke,The Peptides (Academic Press, New York-London 1966), vol. 2, p. 138.

    Google Scholar 

  16. M. Bienert, J. prakt. Chem., in Vorbereitung.

  17. P. Oehme, J. Bergmann, H. Niedrich, F. Jung undG. Menzel, Acta biol. med. germ.25, 613 (1970).

    CAS  Google Scholar 

  18. P. Oehme, J. Bergmann, M. Falck, J. G. Reich, W. E. Vogt, H. Niedrich, J. Pirrwitz, Ch. Berseck undF. Jung, Acta biol. med. germ.28, 109 (1972).

    CAS  Google Scholar 

  19. E. Schnabel undA. Oberdorf, inProtein and Polypeptide Hormones, Proc. Int. Sympos., Liège 1968 (Ed.Margoulis; Excerpta Med. Int. Congress Series, No. 101) p. 224.

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Authors and Affiliations

  1. Bereich Wirkstofforschung, Zentralinstitut für Molekularbiologie der Akademie der Wissenschaften der DDR, Wilhelmstrasse 4, DDR-1136, Berlin-Friedrichsfelde, Deutschland

    J. Bergmann, M. Bienert, H. Niedrich, B. Mehlis & P. Oehme

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  1. J. Bergmann
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  2. M. Bienert
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  3. H. Niedrich
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  4. B. Mehlis
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  5. P. Oehme
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Für zuverlässige Assistenz sei den MitarbeiterinnenM. Eichstädt, M. Kühler undM. Rudel herzlich gedankt.

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Bergmann, J., Bienert, M., Niedrich, H. et al. Über den Einfluss der Kettenlänge bei C-terminalen Sequenzen der Substanz P — in Vergleich mit analogen Physalaemin- und Eledoisin-Peptiden—auf die Wirksamkeit am Meerschweinchen-Ileum. Experientia 30, 401–403 (1974). https://doi.org/10.1007/BF01921687

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  • DOI: https://doi.org/10.1007/BF01921687

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