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Tribenoside as an inhibitor of chemically induced histamine release

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Zusammenfassung

In einem Peritonealzell-System der Ratte zeigt ein Alkyl-Prolyl-Derivat von Corticotrophin (C44 680-Ba) eine grössere Histamin-freisetzende Wirkung als Compound 48/80. Dieser Effekt der beiden Substanzen kann durch Verbindungen gehemmt werden, die antiinflammatorische und/oder anti-allergische Eigenschaften besitzen. Tribenosid (Glyvenol®) und Polyphloretinphosphat erweisen sich als sehr aktive Inhibitoren dieser chemisch induzierten Histamin-Freisetzung, während Diaethylcarbamazin und Dinatriumcromoglycat nur einen geringen Hemmffekt ergeben.

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Authors and Affiliations

  1. Biological Department, Pharmaceutical Division, Ciba-Geigy Ltd., CH-4002, Basel, Switzerland

    M. Rüegg & R. Jaques

Authors
  1. M. Rüegg
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  2. R. Jaques
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Additional information

The skilful technical assistance of MissS. Thorwirth and Mr.U. Niederhauser is gratefully acknowledged.

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Rüegg, M., Jaques, R. Tribenoside as an inhibitor of chemically induced histamine release. Experientia 30, 399–401 (1974). https://doi.org/10.1007/BF01921686

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