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Pénétration intracérébrale de l'harmaline

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Summary

Intracerebral diffusion of a reversible monoamine oxidase inhibitor, harmaline, has been studied in the rat by fluorescence microscopy after i.p. and intraventricular injections. In both cases, any specific uptake of harmaline into the neurons cannot be specified. Nevertheless, in the second case harmaline never seems to reach structures distant by more than 650 μm from the ventricular ependyma. Moreover, some observations tend to support the hypothesis that there is a diffusion of the drug from infundibulum to the subarachnoid space.

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References

  1. J. A. Gunn, Trans. R. Soc. Edinburgh48, 83 (1913).

    Article  Google Scholar 

  2. S. Udenfried, B. Witkop, B. G. Redfield etH. Weissbach, Biochem. Pharmac.1, 160 (1958).

    Article  Google Scholar 

  3. L. J. Poirier, T. L. Sourkes, G. Bouvier, R. Boucher etS. Carabin, Brain89, 37 (1966).

    Article  CAS  Google Scholar 

  4. J. S. Kim, R. Hassler, M. Kurokawa etI. J. Bak, Expl. Neurol.29, 189 (1970).

    Article  CAS  Google Scholar 

  5. J. A. Fuentes etV. G. Longo, Neuropharmacology10, 15 (1971).

    Article  CAS  Google Scholar 

  6. Y. Lamarre, C. de Montigny, M. Dumont etM. M. Weiss, Brain Res.32, 246 (1971).

    Article  CAS  Google Scholar 

  7. Y. Lamarre etL. A. Mercier, Rev. can. Biol.31, Suppl. printemps, 181 (1972).

    Google Scholar 

  8. C. de Montigny etY. Lamarre, Brain Res.53, 81 (1973).

    Article  Google Scholar 

  9. D. F. Downing, Q. Rev. Psychiat. Neurol.16, 133 (1962).

    CAS  Google Scholar 

  10. H. H. Pennes etP. H. Hoch, Am. J. Psychiat.113, 887 (1957).

    Article  CAS  Google Scholar 

  11. R. H. F. Manske, dansThe Alkaloids: The Carboline Alkaloids (Ed.R. H. F. Manske; Academic Press, New-York and London 1965), vol. 8, p. 47.

    Google Scholar 

  12. G. Lascar etC. Bouchaud, Arch. Anat. microsc. Morph. exp.61, 339 (1972).

    CAS  Google Scholar 

  13. A. Ahmed etN. R. W. Taylor, Br. J. Pharmac.14, 350 (1959).

    CAS  Google Scholar 

  14. V. J. Bartoniček, Pharmacology5, 36 (1971).

    Article  Google Scholar 

  15. R. Llìnas etR. A. Volkind, Expl. Brain Res.18, 69 (1973).

    Article  Google Scholar 

  16. C. Bouchaud, C. r. Acad. Sci., Paris270, 108 (1970).

    CAS  Google Scholar 

  17. C. Bouchaud, A. M. Berrou etJ. Peyrichoux, Bull. Ass. anat.151, 252 (1971).

    Google Scholar 

  18. Ce travail a été effectué dans le cadre de la convention D.R.M.E. No. 73/467.

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Authors and Affiliations

  1. Laboratoire de Cytologie et Laboratoire de Biologie Animale, Université Paris VI, 12, rue Cuvier, F-75005, Paris, France

    G. Lascar & C. Bouchaud

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  1. G. Lascar
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  2. C. Bouchaud
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Lascar, G., Bouchaud, C. Pénétration intracérébrale de l'harmaline. Experientia 30, 390–392 (1974). https://doi.org/10.1007/BF01921681

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