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Sodium acetylsalicylate effectiveness against fever induced by leukocytic pyrogen and prostaglandin E1 in the cat

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Zusammenfassung

Fieber wurde durch die intraventrikuläre Injektion gleich wirksamer Dosen von Leukozyten-Pyrogen (LP) und Prostaglandin E1 (PGE1) hervorgerufen. Das Fieber entwickelte sich nach Beginn mit einer für beide Substanzen genau gleichen Anstiegsrate der Temperatur, die Latenzzeit bis zum Fieberbeginn war für LP jedoch länger als für PGE1. Die i.v. Gabe von Natriumsalicylat verzögerte den Beginn, verlangsamte die Anstiegsgeschwindigkeit und setzte das Ausmass des LP-Fiebers herab, es war jedoch ohne Einfluss beim PGE1-Fieber.

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Authors and Affiliations

  1. Department of Pharmacology, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, 10032, New York, New York, USA

    E. P. Schoener & S. C. Wang

Authors
  1. E. P. Schoener
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  2. S. C. Wang
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Additional information

This work was supported by grants No. NS05173 and No. NS00031 from the U.S.P.H.S. The authors would like to thankPhillip Goad for this expert technical assistance.

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Schoener, E.P., Wang, S.C. Sodium acetylsalicylate effectiveness against fever induced by leukocytic pyrogen and prostaglandin E1 in the cat. Experientia 30, 383–384 (1974). https://doi.org/10.1007/BF01921678

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