Riassunto
Gli ioni manganese inibiscono l'aggregazione in vitro di piastrine umane indotta da ADP e da noradrenalina ed in particolare la seconda fase. Il meccanismo consiste probabilmente in una interferenza con l'attività degli ioni calcio.
References
K. Grette, Acta physiol. scand.56, suppl. 195 (1962).
W. W. Douglas, Br. J. Physiol.34, 451 (1968).
S. Ebashi, in Proc. of the 4th Int. Congress on Pharmacology (Ed.E. Eigenmann; Schwabe, Basel 1970), vol. 1, p. 32.
R. P. Rubin, Pharmac. Rev.22, 389 (1970).
G. V. R. Born andM. J. Cross, J. Physiol., Lond.168, 178 (1963).
G. Sacchetti, D. Bellani, C. Montanari andA. Gibelli, Thromb. Diath. Haemorrh.29, 190 (1973).
D. C. B. Mills, I. A. Robb andG. C. K. Roberts, J. Physiol., Lond.195, 715 (1968).
M. B. Zucker, Can. med. Ass. J.108, 445 (1973).
M. Bettex-Galland andE. F. Lüscher, Nature, Lond.184, 276 (1959).
M. G. Davey andE. F. Lüscher, Seminars Hemat.5, 5 (1968).
D. Zucker-Franklin andN. Bloomberg, J. clin. Invest.48, 165 (1969).
P. Fatt andB. L. Ginsborg, J. Physiol., Lond.142, 516 (1958).
R. K. Okrand, J. Physiol., Lond.164, 103 (1962).
S. Hagiwara andS. Nakajima, J. gen. Physiol.49, 793 (1966).
Y. Nonomura, Y. Hotta andH. Ohashi, Science152, 97 (1966).
L. Hurwitz andA. Suria, A. Rev. Pharmac.11, 303 (1971).
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Sacchetti, G., Gibelli, A., Bellani, D. et al. Effect of manganese ions on human platelet aggregation in vitro. Experientia 30, 374–375 (1974). https://doi.org/10.1007/BF01921672
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DOI: https://doi.org/10.1007/BF01921672