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Effects de la Chloroquine sur les activités adénylate cyclasique et phosphodiestérasique de plaquettes humaines

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Summary

chloroquine has no effect on phosphodiesterase activity, but it inhibits the adenyl cyclase activity, of lysed platelets and intact platelets, only when adenine is used as a precursor. Furthermore, it inhibits the effects of thrombin and collagen on adenyl cyclase activity.

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Authors and Affiliations

  1. Laboratoire de Médecine Nucléaire, appliqué à l'Hématologie, Pavillon Ebis (Pr Viala), Hôpital Edouard Herriot, Place d'Arsonval, F-69003, Lyon, France

    M. Dechavanne

  2. Laboratoire d'Hémostase, Institut Pasteur, (J.P. Thouverez), Lyon, France

    M. Lagarde

Authors
  1. M. Dechavanne
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  2. M. Lagarde
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Dechavanne, M., Lagarde, M. Effects de la Chloroquine sur les activités adénylate cyclasique et phosphodiestérasique de plaquettes humaines. Experientia 30, 34–35 (1974). https://doi.org/10.1007/BF01921580

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  • DOI: https://doi.org/10.1007/BF01921580

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