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On the regulation of lactate dehydrogenase isoenzyme concentrations in mammalian cells

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Zusammenfassung

Fritz et al.3 haben in Nature New Biol. 230, 119 ein Modell publiziert, mit dem sie die Regulation der intrazellulären LDH-Isoenzym-Konzentration erklären. Die vorliegende Arbeit zeigt, dass die Resultate vonFritz et al. einfacher durch Heterogenität der Zellen des untersuchten Gewebes erklärt werden kann als durch ihr Modell mit „non-random association” der LDH-Untereinheiten und verschiedenen „turnover”-Raten der Isoenzyme in derselben Zelle.

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Additional information

I thank Drs.Ursprung, D. Turner, D. Seybold andH. Eppenberger for helpful discussions. This work was supported by the Swiss National Science Foundation, Project No. 3.247.69.

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Lebherz, H.G. On the regulation of lactate dehydrogenase isoenzyme concentrations in mammalian cells. Experientia 30, 655–658 (1974). https://doi.org/10.1007/BF01921528

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