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Sensitivity of mesenteric vascular bed to vasoconstrcctor drugs during reactive hyperemia

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Zusammenfassung

Nachweis, dass die Reaktion der mesenterialen Blutgefässe beim Hund nach einmaliger intraarterieller Injektion von Angiotensin oder Noradrenalin während der durch die 2,5 min andauernden arteriellen Oklusion ausgelösten reaktiven Hyperämie herabgfesetzt wird. Diese Verminderung der vasokonstriktorischen Reaktion dürfte insbesondere auf eine Sensibilitätsverminderung der Gefässmuskeln auf die Pharmaka und dessen bei der reaktiven Hyperämie verminderten pO2 in Blut und Gewebe zurückzuführen sein.

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Literatur

  1. R. Detar andD. F. Bohr, Am. J. Physiol.214, 241 (1968).

    Article  CAS  PubMed  Google Scholar 

  2. A. C. Guyton, J. M. Ross, O. Carrier Jr. andJ. R. Walker, Circulation Res. Suppl. to14–15, 1–60 (1964).

    Google Scholar 

  3. S. Štolc andF. V. Selecký, Eur. J. Pharmac.7, 31 (1969).

    Article  Google Scholar 

  4. E. E. Selkurt, C. F. Rothe andD. Richardson, Circulation Res.15, 532 (1964).

    Article  CAS  PubMed  Google Scholar 

  5. The canine intestine goes into an oxygen debt approximately in 1 min of complete ischemia4. In our experiments ischemia lasted 2.56±0.08 min, hence the oxygen debt apparently occured. Using data for tissue blood volumes and oxygen consumption found bySelkurt et al.4 the oxygen debt can be calculated. It was approximately 1.2 ml O2/100 g of tissue at the end of the occlusion period and was repayed approximately 1.1 min after restarding of perfusion.

  6. S. Shibata andA. H. Briggs, Am. J. Physiol.212, 981 (1967).

    Article  CAS  PubMed  Google Scholar 

  7. F. P. McGinn, D. Mendel andP. M. Perry, J. Physiol., Lond.192, 669 (1967).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. F. J. Haddy andJ. B. Scott, Physiol. Rev.48, 688 (1968).

    Article  CAS  PubMed  Google Scholar 

  9. P. D. Redleaf andL. Tobian, Circulation Res.6, 185 (1958).

    Article  CAS  PubMed  Google Scholar 

  10. M. E. Abrams, D. J. P. Barker andW. H. J. Butterfield, Clin. Sci.29, 565 (1965).

    CAS  PubMed  Google Scholar 

  11. B. Folkow, Circulation Res. Suppl. to14–15, 1–59 (1964).

    Google Scholar 

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Authors and Affiliations

  1. Institute of Experimental Pharmacology, Slovak Academy of Sciences, P.O. Box 1041, CS-88105, Bratislava, Czechoslovakia

    S. Štolc

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  1. S. Štolc
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Štolc, S. Sensitivity of mesenteric vascular bed to vasoconstrcctor drugs during reactive hyperemia. Experientia 30, 644–645 (1974). https://doi.org/10.1007/BF01921521

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