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Urinary excretion of methylated purines following inhalation of dimethyl sulphate

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Zusammenfassung

Nach Inhalation des alkylierenden Agens Dimethylsulfat wurden im Urin von Mäusen methylierte Purine in Mengen von etwa 0,3% der Dimethylsulfatdosis ausgeschieden. Auch bei einer 100-fachen Expositionsverminderung mit radioaktivem Dimethalsulfat wird ungefähr der gleiche relative Anteil an markierten Purinen eliminiert.

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Literatur

  1. H. Druckrey, R. Preussmann, N. Nashed andS. Ivankovic, Z. Krebsforsch.68, 103 (1966).

    Article  CAS  PubMed  Google Scholar 

  2. F. A. Schlögel andP. Bannasch, Naunyn-Schmiedebergs Arch. Pharmak.266, 441 (1970).

    Google Scholar 

  3. H. Druckrey, H. Kruse, R. Preussmann, S. Ivankovic andCh. Landschütz, Z. Krebsforsch.74, 241 (1970).

    Article  CAS  PubMed  Google Scholar 

  4. P. F. Swann andP. N. Magee, Biochem. J.110, 39 (1968).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. P. D. Lawley andS. A. Shah, Chem. biol. Interact.7, 115 (1973).

    Article  CAS  PubMed  Google Scholar 

  6. P. D. Lawley, Chem. biol. Interact.7, 127 (1973).

    Article  CAS  PubMed  Google Scholar 

  7. D. B. Ludlum, J. biol. Chem.245, 477 (1970).

    Article  CAS  PubMed  Google Scholar 

  8. L. L. Gerchman andD. B. Ludlum, Biochim. biophys. Acta308, 310 (1973).

    Article  CAS  PubMed  Google Scholar 

  9. P. D. Lawley andP. Brookes, Biochem. J.89, 127 (1963).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. G. P. Margison, M. J. Capps, P. J. O'Connor andA. W. Craig, Chem. biol. Interact.6, 119 (1973).

    Article  CAS  PubMed  Google Scholar 

  11. M. J. McElhone, P. J. O'Connor andA. W. Craig, Biochem. J.125, 821 (1971).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. V. M. Craddock, A. R. Mattocks andP. N. Magee, Biochem. J.109, 75 (1968).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. V. M. Craddock,andP. N. Magee, Biochem. J.104, 435 (1967).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. J. L. Skibba andG. T. Bryan, Toxic. appl. Pharmac.18, 707 (1971).

    Article  CAS  Google Scholar 

  15. B. C. F. Chu andP. D. Lawley, Chem. biol. Interact.8, 65 (1974).

    Article  CAS  PubMed  Google Scholar 

  16. R. Wennerberg andG. Löfroth, Chem. biol. Interact.8, 339 (1974).

    Article  CAS  PubMed  Google Scholar 

  17. J. Epstein, R. W. Rosenthal andR. J. Ess, Analyt. Chem.27, 1435 (1965).

    Article  Google Scholar 

  18. B. Singer andH. Fraenkel-Conrat, Biochemistry8, 3260 (1969).

    Article  CAS  PubMed  Google Scholar 

  19. P. D. Lawley andC. J. Thatcher, Biochem. J.116, 693 (1970).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. P. D. Lawley andS. A. Shah, Biochem. J.128, 117 (1972).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. I. G. Walker andD. F. Ewart, Mutation Res.19, 331 (1973).

    Article  CAS  PubMed  Google Scholar 

  22. P. J. O'Connor, M. J. Capps andA. W. Craig, Br. J. Cancer27, 153 (1973).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Radiobiology Department, University of Stockholm, Wallenberg Laboratory, Lilla Frescati, S-104 05, Stockholm 50, Sweden

    G. Löfroth, S. Osterman-Golkar & R. Wennerberg

Authors
  1. G. Löfroth
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  2. S. Osterman-Golkar
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  3. R. Wennerberg
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Additional information

Acknowledgements: We thank Dr.P. D. Lawley of the Chester Beatty Research Institute for the gift of 3-methyladenine. This investigation is supported by a graht from the Swedish Medical Research Council.

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Löfroth, G., Osterman-Golkar, S. & Wennerberg, R. Urinary excretion of methylated purines following inhalation of dimethyl sulphate. Experientia 30, 641–642 (1974). https://doi.org/10.1007/BF01921519

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  • DOI: https://doi.org/10.1007/BF01921519

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