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Delayed neurodegeneration induced by extracellular lactacidity and neuroprotection by basic fibroblast growth factor in rat hippocampal neurons

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Conclusion

Moderate extracellular lactacidity induces a delayed form of neuronal injury. bFGF administered after the insult significantly attenuated the neurodegeneration. It may therefore have a therapeutic value in the setting of cerebral lactacidity in vivo.

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References

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Authors and Affiliations

  1. University Clinic of Anesthesiology, Ulm, Germany

    Himmelseher S, Pfenninger E & Georgieff M

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  1. Himmelseher S
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  2. Pfenninger E
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  3. Georgieff M
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Himmelseher, S., Pfenninger, E. & Georgieff, M. Delayed neurodegeneration induced by extracellular lactacidity and neuroprotection by basic fibroblast growth factor in rat hippocampal neurons. Intensive Care Med 22 (Suppl 1), S97 (1996). https://doi.org/10.1007/BF01921271

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  • DOI: https://doi.org/10.1007/BF01921271

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